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Fluorinated VHL Spy Molecule 2

Fluorinated VHL Spy Molecule 2 Struktur
2290526-27-9
CAS-Nr.
2290526-27-9
Englisch Name:
Fluorinated VHL Spy Molecule 2
Synonyma:
Fluorinated VHL Spy Molecule 2;(2S,4R)-N-[(4-bromophenyl)methyl]-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide;2-Pyrrolidinecarboxamide, N-[(4-bromophenyl)methyl]-4-hydroxy-1-(2,2,2-trifluoroacetyl)-, (2S,4R)-;(2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide, VHL reporter ligand
CBNumber:
CB25541856
Summenformel:
C14H14BrF3N2O3
Molgewicht:
395.17
MOL-Datei:
2290526-27-9.mol

Fluorinated VHL Spy Molecule 2 Eigenschaften

Siedepunkt:
624.2±55.0 °C(Predicted)
Dichte
1.637±0.06 g/cm3(Predicted)
pka
13.62±0.40(Predicted)
Aggregatzustand
powder

Sicherheit

Fluorinated VHL Spy Molecule 2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Fluorinated VHL Spy Molecule 2 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909459, 909440, and 909416.
The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.

Fluorinated VHL Spy Molecule 2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fluorinated VHL Spy Molecule 2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 6)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Jilin Province Woda Biotechnology Co., Ltd. 13504435624
1927928688@qq.com China 1466 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822
czbjpharma@126.com China 18478 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 13417589054
trendseenbio@gmail.com China 9470 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826
market@aladdin-e.com China 48461 58

  • Fluorinated VHL Spy Molecule 2
  • 2-Pyrrolidinecarboxamide, N-[(4-bromophenyl)methyl]-4-hydroxy-1-(2,2,2-trifluoroacetyl)-, (2S,4R)-
  • (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide, VHL reporter ligand
  • (2S,4R)-N-[(4-bromophenyl)methyl]-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide
  • 2290526-27-9
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