ANTI-ATM ANTIBODY,MOUSE MONOCLONAL Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Monoclonal Anti-ATM antibody can be used in immunoblotting , ELISA and immunoprecipitation.
Allgemeine Beschreibung
Monoclonal Anti-ATM (mouse IgG1 isotype) is derived from the hybridoma MAT3-4G10/8 produced by the fusion of mouse myeloma cells (NSO) and splenocytes from BALB/c mice immunized with a peptide.
Biochem/physiol Actions
Anti-Ataxia-Telangiectasia Mutated (ATM) is responsible for the activation and stabilization of p53 in response to double-strand break (DSB). ATM phosphorylates p53 directly on Ser15 and concomitantly activates other kinases that phosphorylate the same molecule on additional sites. Furthermore, human homolog of double minute 2 (Hdm2) is phosphorylated by ATM on Ser395 and this phosphorylation inhibits Hdm2-mediated degradation of p53.
ANTI-ATM ANTIBODY,MOUSE MONOCLONAL Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
