E3 ligase Ligand-Linker Conjugates 12 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block (S,R,S)-AHPC-PEG₃-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 12 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

E3 ligase Ligand-Linker Conjugates 12 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4825	58
Tianjin heowns Biochemical Technology Co., Ltd.	400-6387771-6037 18920794737	sales@heowns.com	China	23074	60
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1466	58
Shaanxi borno biotechnology co., LTD	+86-13759708231	asherw9@hotmail.com	China	2373	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Shanghai Kaiwei Chemical Technology Co., Ltd.	021-58461859 15821823057	service@aiviche.com	China	49312	58

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• E3 ligase Ligand-Linker Conjugates 12
• (S,R,S)-AHPC-PEG3-azide
• VH032-PEG3-N3
• VHL Ligand-Linker Conjugates 8
• (S,R,S) AHPC PEG3 N3,(S,R,S)-AHPC-PEG-3-N3,Inhibitor,inhibit,E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG3N3
• (2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
• (S,R,S)-AHPC-PEG?-azide
• (2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
• L-Prolinamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• (S,R,S)-AHPC-PEG3-N3 (VH032-PEG3-N3)
• 1797406-80-4