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4'-CHLORO-3-METHOXYCINNAMANILIDE

4'-CHLORO-3-METHOXYCINNAMANILIDE Struktur
472981-92-3
CAS-Nr.
472981-92-3
Englisch Name:
4'-CHLORO-3-METHOXYCINNAMANILIDE
Synonyma:
SB 366791;SB366791, >98%;SB 366791;SB366791;4'-CHLORO-3-METHOXYCINNAMANILIDE;4'-CHLORO-3-METHOXYCINNAMANILIDE;N-(3-METHOXYPHENYL)-4-CHLOROCINNAMIDE;4'-CHLORO-3-METHOXYCINNAMANILIDE(SB366791);3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide;(E)-3-(4-CHLOROPHENYL)-N-(3-METHOXYPHENYL)ACRYLAMIDE;3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
CBNumber:
CB2449409
Summenformel:
C16H14ClNO2
Molgewicht:
287.74
MOL-Datei:
472981-92-3.mol

4'-CHLORO-3-METHOXYCINNAMANILIDE Eigenschaften

Schmelzpunkt:
165-167℃
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMSO: 13 mg/mL, soluble
Aggregatzustand
solid
Farbe
off-white
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3
HS Code  2924.29.7790

4'-CHLORO-3-METHOXYCINNAMANILIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

N-(4-Methoxyphenyl)-4-chlorocinnamamide is a novel, potent, and selective cinnamide TRPV1 antagonist. Also a useful tool to further study the biology of TRPV1.

Biologische Aktivit?t

Potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA 2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB 1 and CB 2 receptors, voltage-gated Ca 2+ channels and the hyperpolarization-activated current (I h ). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .

Biochem/physiol Actions

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.

4'-CHLORO-3-METHOXYCINNAMANILIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4'-CHLORO-3-METHOXYCINNAMANILIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • N-(3-METHOXYPHENYL)-4-CHLOROCINNAMIDE
  • SB 366791
  • 4'-CHLORO-3-METHOXYCINNAMANILIDE
  • 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
  • (E)-3-(4-CHLOROPHENYL)-N-(3-METHOXYPHENYL)ACRYLAMIDE
  • 2-Propenamide,3-(4-chlorophenyl)-N-(3-methoxyphenyl)-
  • SB 366791;SB366791
  • SB366791, >98%
  • 4'-CHLORO-3-METHOXYCINNAMANILIDE(SB366791)
  • 4'-CHLORO-3-METHOXYCINNAMANILIDE
  • 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide
  • 472981-92-3
  • C16H14NO2Cl
  • Vanilloid/TRPV channel
  • API
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