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Valaciclovir

Valaciclovir Struktur
124832-26-4
CAS-Nr.
124832-26-4
Englisch Name:
Valaciclovir
Synonyma:
VALACYCLOVIR;VALACICLOVIR HYDROCHLORIDE;VALACICLOVIR HCL;256U87;VALACV;Valcivir;VALACICLOVIR;100MG/1G/1KG;Valacyclovir-d4;ValaciclovirBase
CBNumber:
CB2379191
Summenformel:
C13H20N6O4
Molgewicht:
324.34
MOL-Datei:
124832-26-4.mol

Valaciclovir Eigenschaften

Dichte
1.55±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
Powder
pka
9.34±0.20(Predicted)
EPA chemische Informationen
L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester (124832-26-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
Giftige Stoffe Daten 124832-26-4(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Valaciclovir Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White Solid

Verwenden

The L-Valine ester prodrug of Acyclovir.
Valacyclovir Tablets
Valacyclovir (Valtrex) is the 1-valine ester (prodrug) of acyclovir that exhibits no activity until hydrolyzed in the intestinal wall or liver to acyclovir and its active metabolite. Its modified structure allows increased intestinal absorption and concomitant higher plasma levels of acyclovir. It demonstrates activity against HSV types 1 and 2, varicella-zoster virus, and cytomegalovirus. It exerts its effects by interfering with DNA synthesis through phosphorylation by viral thymidine kinase and subsequent inhibition of viral DNA polymerase, thereby inhibiting viral replication. Valtrex is indicated for the treatment of acute herpes zoster and recurrent genital herpes in immunocompetent adults. The most common side effects are headache, nausea, and vomiting.

Indications

Valacyclovir (Valtrex) is the 1-valine ester (prodrug) of acyclovir that exhibits no activity until hydrolyzed in the intestinal wall or liver to acyclovir and its active metabolite. Its modified structure allows increased intestinal absorption and concomitant higher plasma levels of acyclovir. It demonstrates activity against HSV types 1 and 2, varicella-zoster virus, and cytomegalovirus. It exerts its effects by interfering with DNA synthesis through phosphorylation by viral thymidine kinase and subsequent inhibition of viral DNA polymerase, thereby inhibiting viral replication. Valtrex is indicated for the treatment of acute herpes zoster and recurrent genital herpes in immunocompetent adults. The most common side effects are headache, nausea, and vomiting.
Valacyclovir is the only antiviral agent approved for herpes labialis, for a 3-day course in the episodic treatment of recurrent genital herpes (2). Valacyclovir is indicated for recurrent genital herpes and is administered at 500 mg twice daily for 3 days at the onset of prodromal symptoms or at the first sign of infection.

Pharmakologie

Valacyclovir (Valtrex), a valine ester prodrug of acyclovir, has a bioavailability three to five times that of acyclovir. This is due to its improved gastrointestinal absorption compared to acyclovir. Valacyclovir is rapidly and almost completely converted to acyclovir after oral administration, with levels comparable to those of intravenous acyclovir. This allows for twice-daily dosing, which may improve compliance and ultimate clinical efficacy. It is more costly than acyclovir.

Valaciclovir Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Valaciclovir Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 226)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
1012@dideu.com China 3003 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Xi'an MC Biotech, Co., Ltd.
029-89275612 +8618991951683
mcbio_sales@163.com China 2251 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22785 58

124832-26-4()Verwandte Suche:


  • Valaciclovir & Valaciclovir Hydrochloride
  • Valacyclovir-d4
  • L-VALINE 2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9YL)METHOXY]ETHYL ESTER
  • L-VALINE 2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9YL)METHOXY]ETHYL ESTER, HYDROCHLORIDE SALT
  • l-valine 2-(guanin-9-ylmethoxy)ethyl ester
  • VALACICLOVIR
  • VALACV
  • VALACICLOVIR 99+%
  • ValaciclovirBase
  • Valaciclovir Hydrochloride 124832-27-5 / Base
  • 256U87
  • L-Valine ester with 9-[(2-hydroxyethoxy)methyl]guanine
  • L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester (9CI)
  • 100MG/1G/1KG
  • Valcivir
  • Valacyclovir Hydrochloride Hydrate (L-Valine 2-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-ylmethoxy)ethyl Ester Hydrochloride hydrate
  • Valaciclovir USP/EP/BP
  • ValacyclovirQ: What is Valacyclovir Q: What is the CAS Number of Valacyclovir Q: What is the storage condition of Valacyclovir Q: What are the applications of Valacyclovir
  • VALACICLOVIR HCL
  • VALACICLOVIR HYDROCHLORIDE
  • VALACYCLOVIR
  • 124832-26-4
  • C13H20N6O4
  • C13H12N6O4D8HCl
  • C13H20N6O4HCl
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