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Phorbol-(12-myristol-13-acetyl)

PHORBOL 12-MYRISTATE 13-ACETATE Struktur
16561-29-8
CAS-Nr.
16561-29-8
Bezeichnung:
Phorbol-(12-myristol-13-acetyl)
Englisch Name:
PHORBOL 12-MYRISTATE 13-ACETATE
Synonyma:
TPA;12-O-TETRADECANOYLPHORBOL 13-ACETATE;Recombinant Human Tissue Plasminogen Activator;phorbol ester;factora1;,9aalpha))-;Cocarcinogen A1;Cocarcinogen C3;pma(tumorpromoter);factora1(crotonoil)
CBNumber:
CB2376433
Summenformel:
C36H56O8
Molgewicht:
616.83
MOL-Datei:
16561-29-8.mol

Phorbol-(12-myristol-13-acetyl) Eigenschaften

Schmelzpunkt:
65-79oC
Siedepunkt:
571.87°C (rough estimate)
Dichte
1.17±0.1 g/cm3 (20 ºC 760 Torr)
Brechungsindex
1.4900 (estimate)
storage temp. 
-20°C
L?slichkeit
DMSO: DMSO solutions can be stored dark at −20°C for at least six months.soluble
pka
11.19±0.70(Predicted)
Aggregatzustand
Fine Crystalline Powder
Farbe
Off-white to light yellow
Wasserl?slichkeit
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Sensitive 
Light Sensitive
BRN 
2407201
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey
PHEDXBVPIONUQT-RGYGYFBISA-N
CAS Datenbank
16561-29-8(CAS DataBase Reference)
EPA chemische Informationen
12-O-Tetradecanoylphorbol 13-acetate (16561-29-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 38-36/37/38
S-S?tze: 36/37-26
RIDADR  2928
WGK Germany  3
RTECS-Nr. QH4377000
8-10
HazardClass  6.1(a)
PackingGroup  II
HS Code  29153900
Giftige Stoffe Daten 16561-29-8(Hazardous Substances Data)
Toxizit?t Diesters of phorbol, particularly 12-O-tetradecanoylphorbol 13-acetate, also known as phorbol myristate acetate, have been identified as the potent, highly lipophilic tumor-promoting components in croton oil. They are potent promoters of skin tumors in vivo and have been shown to transform cultured fibroblasts and embryonic cells previously exposed to polycyclic aromatic hydrocarbon carcinogens in vitro. The structure of phorbol, the parent alcohol is shown below. Phorbol esters also have important effects on leukocytes and on the immune system of the intact animal. There appears to be a specific receptor for phorbol esters on T cells, a finding that may account for the selective toxicity of phorbol esters for T cells. The mechanism of tumor promotion by phorbol esters is still largely unknown, but findings suggest an initial cell membrane interaction (often with stimulation of second messenger synthesis and increased protein kinase activity), with subsequent effects on nuclear regulatory events.
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H314 Verursacht schwere Ver?tzungen der Haut und schwere Augensch?den. ?tzwirkung auf die Haut Kategorie 1B Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P261, P285, P304+P341, P342+P311,P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P303+P361+P353 BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Phorbol-(12-myristol-13-acetyl) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R38:Reizt die Haut.

S-S?tze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Chemische Eigenschaften

white to off-white solid

Verwenden

4β-Phorbol 12-Myristate 13-Acetate is used in the activation of certain pyruvate kinases as well as protein kinases.

Allgemeine Beschreibung

White crystals.

Air & Water Reaktionen

Practically water insoluble.

Reaktivit?t anzeigen

PHORBOL 12-MYRISTATE 13-ACETATE is sensitive to acids and alkalis. .

Brandgefahr

Flash point data for PHORBOL 12-MYRISTATE 13-ACETATE are not available; however, PHORBOL 12-MYRISTATE 13-ACETATE is probably combustible.

Biologische Aktivit?t

Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a K i value of 2.6 nM as measured by displacement of [ 3 H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.

Phorbol-(12-myristol-13-acetyl) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Phorbol-(12-myristol-13-acetyl) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 245)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12795 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20288 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9218 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 3000 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
+8613815430202
sale02@cqherb.com CHINA 376 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

16561-29-8(Phorbol-(12-myristol-13-acetyl))Verwandte Suche:


  • 13-o-acetylphorbol12-myristate
  • 4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
  • 5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
  • 4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
  • 4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
  • 4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
  • (1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
  • 12-TETRADECANOYL PHORBOL 13-ACETATE
  • PHORBOL 12-MYRISTATE 13-ACETATE, SYNTHET IC
  • PHORBOL 12-MYRISTATE 13-ACETATE,*MOLECUL AR BIOLOGY
  • PHORBOL 12-MYRISTATE 13-ACETATE FROM &
  • Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa3,4benz1,2-eazulen-9-yl ester
  • 4B-PHORBOL-12-MYRISTATE-13-ACETATE
  • 2-ORTHO-TETRADECANOYL-PHORBOL-13-ACETATE
  • O-TETRADECANOYLPHORBOL-13-ACETATE
  • 12-ORTHO-TETRADECANOYLPHORBOL-13-ACETATE
  • 12-O-Tetradecanoylphorbol 13-acetate, PMA, TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
  • Phorbol 12-myristate 13-acetate,99%
  • Phorbol 12-myristate 13-acetate,97%
  • PHORBOL(12-MYRISTOYL-13-ACETYL) ANALYTICAL GRADE
  • Phorbol 12-myristate 13-acetate,12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA
  • Phorbol 12-Myristate 13-Acetate >99.5%
  • Phorbol-12-Myristate-13-acetate / 12-Tetradecanoyl phorbol-13-acetate, TPA
  • PMA, TPA, Cocarcinogen A1
  • 12-O-TETRADECANOYL PHORBOL-13-ACETATE;COCARCINOGEN A1; COCARCINOGEN C3
  • Cocarcinogen A1
  • Cocarcinogen C3
  • (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
  • 12-O-tetradecanoyl phorbol-13-acetate(CAS:16561-29-8)
  • 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
  • PHORBOL 12-MYRISTATE 13-ACETATE, SYN
  • (1AR,1bS,4aR,7aS,7bS,8R,9R,9aS)
  • -1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
  • -9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)
  • InSolution? Phorbol-12-myristate-13-acetate
  • PHORBOL 12-MYRISTATE 13-ACETATE
  • PHORBOL (12-MYRISTOYL-13-ACETYL)
  • 8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy
  • abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram
  • a-tetramethyl-5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,9a-acetate
  • -e)azulen-9-ylester,(1ar-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta
  • factora1
  • factora1(crotonoil)
  • factora1[crotonoil]
  • hydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1h-cyclopropa(3,4)benz(1,2
  • myristicacid,9-esterwith1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-decahydr
  • myristicacid,9-esterwith1,1aalpha,1bbeta,4,4a,7aalpha,7b,8,9,9a-decahydro-4
  • o-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-alph
  • pentahydroxy-tigliadienone-monoacetate(c)monomyristate(b)
  • phorbol12-tetradecanoate13-acetate
  • phorbolacetate,myristate
  • phorbolmonoacetatemonomyristate
  • phorbolmyristateacetate
  • pma(tumorpromoter)
  • tetradecanoicacid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-di
  • tetradecanoylphorbolacetate
  • ,9aalpha))-
  • 1,6,8-beta-tetramethyl-l)-9a-acetate9-myristate
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