E3 ligase Ligand-Linker Conjugates 3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block (S,R,S)-AHPC-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

E3 ligase Ligand-Linker Conjugates 3 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	7312	58
Heze Development Zone chuangli Chemical Co., Ltd.	+86-530-529 6766，+86-15666160102 15666160102	info@chuangli-chem.com	China	899	55
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4825	58
Tianjin heowns Biochemical Technology Co., Ltd.	400-6387771-6037 18920794737	sales@heowns.com	China	23074	60
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1466	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58
Shaanxi borno biotechnology co., LTD	+86-13759708231	asherw9@hotmail.com	China	2373	58

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• E3 ligase Ligand-Linker Conjugates 3
• (S,R,S)-AHPC-PEG1-azide
• VH032-PEG1-N3
• VHL Ligand-Linker Conjugates 9
• E3 Ligase Ligand-Linker Conjugates,(S,R,S) AHPC PEG1 N3,Inhibitor,(S,R,S)-AHPC-PEG-1-N3,(S,R,S)AHPCPEG1N3,inhibit
• (2S,4R)-1-((S)-2-(2-(2-azidoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
• L-Prolinamide, N-[2-(2-azidoethoxy)acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• (S,R,S)-AHPC-PEG1-N3, 10 mM in DMSO
• 2101200-09-1