2'2'-cGAMP Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; K_d = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (K_ds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC₅₀s = 15.8 and 19.4 nM, respectively, in L929 cells).

2'2'-cGAMP Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2'2'-cGAMP Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14055	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24647	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	6813	58

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• 2'2'-cGAMP
• 2’2’-cGAMP (sodium salt)
• 2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide
• adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
• 2'2'-cGAMP (sodium salt)
• 2’2’-cGAMP
• adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
• 1465774-27-9