DEMETHYLASTERRIQUINONE B1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Demethylasterriquinone B1 (DMAQ B1) is a natural insulin mimic that activates insulin receptor tyrosine kinase (IRTK; EC
50 = 6 μM). It less potently activates IGF1R and EGFR (EC
50s = 100 μM for both). DMAQ B1 induces glucose uptake in adipocytes and skeletal muscle cells without activating proliferation. DMAQ B1 binds GAPDH
in vitro.
Biologische Aktivit?t
Selective insulin receptor (IR) activator/mimetic (EC 50 values are 3-6 μ M for IRTK and 100 μ M for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and downstream activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro , without enhancing vascular proliferation. Binds GAPDH.
DEMETHYLASTERRIQUINONE B1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte