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ACT-335827

ACT-335827 Struktur
1354039-86-3
CAS-Nr.
1354039-86-3
Englisch Name:
ACT-335827
Synonyma:
ACT-335827;ACT 335827; ACT335827;ACT-335827,CID 54765113;(aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide;(2R)-2-[(1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-isopropyl-2-phenyl-acetamide;(2R)-2-[(1S)-1-[(3,4-DIMETHOXYPHENYL)METHYL]-6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL]-2-PHENYL-N-PROPAN-2-YLACETAMIDE;2(1H)-Isoquinolineacetamide, 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-α-phenyl-, (αR,1S)-
CBNumber:
CB23038493
Summenformel:
C31H38N2O5
Molgewicht:
518.65
MOL-Datei:
1354039-86-3.mol

ACT-335827 Eigenschaften

Siedepunkt:
664.0±55.0 °C(Predicted)
Dichte
1.144±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
<51.86mg/ml in DMSO; <51.86mg/ml in ethanol
Aggregatzustand
solid
pka
14.75±0.46(Predicted)
Farbe
Off-white

Sicherheit

ACT-335827 Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This brain-penetrant and orally available orexin receptor antagonist (FW = 518.64 g/mol; CAS 1354039-86-3; Soluble to 100 mM in DMSO, also known as (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinoline acetamide, elicits its anxiolytic effects in vivo by targeting OX1 (Ki = 41 nM) and OX2 (Ki = 560 nM) receptors. ACT-335827 decreases fear, compulsive behaviors, and autonomic stress reactions in rats.

ACT-335827 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ACT-335827 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 16)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
AdooQ BioScience, LLC +1 (866) 930-6790
info@adooq.com United States 2782 58
Jinan Yaoyan Pharmaceutical Co., Ltd.
jnyaoyan@163.com China 3069 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com
meitaochem@126.com China 19103 58
BOC Sciences --
 info@bocsci.com USA 0 65
Absin Bioscience Inc. 021-38015121 15000105423
 wulan@absin.cn China 24731 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8617 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24644 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581
 sales@chemhifuture.com China 5018 58
  • ACT-335827
  • ACT 335827; ACT335827
  • (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide
  • (2R)-2-[(1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-isopropyl-2-phenyl-acetamide
  • ACT-335827,CID 54765113
  • (2R)-2-[(1S)-1-[(3,4-DIMETHOXYPHENYL)METHYL]-6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL]-2-PHENYL-N-PROPAN-2-YLACETAMIDE
  • 2(1H)-Isoquinolineacetamide, 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-α-phenyl-, (αR,1S)-
  • 1354039-86-3
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