Anti-Placental bikunin antibody produced in rabbit Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
SPINT2 (serine peptidase inhibitor, Kunitz type, 2) is a transmembrane Kunitz-type serine protease inhibitor, which contains two Kunitz-type domains. This protein is also called hepatocyte growth factor activator (HGFA) inhibitor 2 (HAI-2). It has a wide range of tissue expression, with predominant expression in kidney, prostate and placenta. It is also expressed in the non-epithelial cells in brain and lymph nodes.
Biochem/physiol Actions
SPINT2 (serine peptidase inhibitor, Kunitz type, 2) is responsible for suppressing the enzyme hepatocyte growth factor activator (HGFA), which converts hepatocyte growth factor (HGF) in its active form. It might play a role in homeostasis of ions in intestine, and mutations in this gene are linked to syndromic congenital sodium diarrhea. It is up-regulated in cholangiopathies, and impacts fibrosis and differentiation of liver. In mice, it plays an essential role in the survival of embryo, placental development and neural tube closure. It inhibits a variety of serine proteases such as, pancreatic trypsin, plasmin, kallikrein. It is a putative tumor suppressor gene, and is down-regulated in certain solid cancers. It is under-expressed in Myelodysplastic syndromes (MDS), and alters the adhesion of mesenchymal stromal cells (MSCs) to pluripotent stem cells or leukemia cells. This leads to the maintenance of abnormal survival, proliferation and self-renewal of pluripotent stem cells, contributing to the pathophysiology of MDS.
Anti-Placental bikunin antibody produced in rabbit Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
