N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

118290-26-9

CAS-Nr.: 118290-26-9

Englisch Name:: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Synonyma:: AF-DX-384; AF-DX384;AF-DX 384 Free Base;N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-

CBNumber:: CB22751069

Summenformel:: C27H38N6O2

Molgewicht:: 478.63

MOL-Datei:: 118290-26-9.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 16

N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Eigenschaften

Siedepunkt:: 618.4±55.0 °C(Predicted)

Dichte: 1.144±0.06 g/cm3(Predicted)

storage temp.: room temp

L?slichkeit: DMSO: soluble10mg/mL, clear (warmed)

pka: 11.55±0.20(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

WGK Germany	3

N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AF-DX 384 is an antagonist of M₂ and M₄ muscarinic acetylcholine receptors (K_is = 6.03 and 10 nM, respectively). It is selective for M₂ and M₄ over M₁, M₃, and M₅ receptors (K_is = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 μM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg. It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine .

N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 16)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2782	58
BOC Sciences	--	info@bocsci.com	USA	0	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Absin Bioscience Inc.	021-38015121 15000105423	wulan@absin.cn	China	24731	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24644	58
Aikon International Limited	18626450290	yftan@aikonchem.com	China	10715	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4988	58

AF-DX 384 Free Base
AF-DX-384; AF-DX384
N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-
118290-26-9

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