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N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate

N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Struktur
675599-62-9
CAS-Nr.
675599-62-9
Englisch Name:
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate
Synonyma:
PG 01037 2HCl;PG-01037 (hydrochloride);PG01037 dihydrochloride hydrate;N-[(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridyl)benzamide dihydrochloride hydrate;N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate
CBNumber:
CB22750471
Summenformel:
C26H30Cl4N4O2
Molgewicht:
572.354
MOL-Datei:
675599-62-9.mol

N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Eigenschaften

Schmelzpunkt:
230-232 °C(Solv: isopropanol (67-63-0))
storage temp. 
2-8°C
L?slichkeit
H2O: ≥8mg/mL at ~60°C
Aggregatzustand
powder
Farbe
white to tan

Sicherheit

WGK Germany  3

N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PG-01037 is a selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively). It inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM). PG-01037 (32 mg/kg) reduces progressive-ratio methamphetamine self-administration in rats allowed extended access. It reduces loss of dopaminergic neurons in the substantia nigra pars compacta and improves motor performance in the coat-hanger test in a mouse model of Parkinson''s disease induced by MPTP.

Verwenden

PG01037 dihydrochloride is a selective D3DR antagonist.

N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 16)Lieferanten
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Jinan Jiuli Biotechnology Co. , Ltd. 15865264761
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TargetMol Chemicals Inc. 4008200310
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Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
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  • N-[(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridyl)benzamide dihydrochloride hydrate
  • N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate
  • PG01037 dihydrochloride hydrate
  • PG-01037 (hydrochloride)
  • PG 01037 2HCl
  • 675599-62-9
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