成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

MI-503

MI-503 Struktur
1857417-13-0
CAS-Nr.
1857417-13-0
Englisch Name:
MI-503
Synonyma:
mi503;M1-503;mi-503;CS-1946;MI503;MI 503;Inhibitor,MI503,inhibit,MI 503,MI-503,Epigenetic Reader Domain;1-((1H-Pyrazol-4-yl)methyl)-4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-;1-((1H-Pyrazol-4-yl)methyl)-4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile;1H-Indole-2-carbonitrile, 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
CBNumber:
CB22747932
Summenformel:
C28H27F3N8S
Molgewicht:
564.63
MOL-Datei:
1857417-13-0.mol

MI-503 Eigenschaften

Siedepunkt:
782.9±60.0 °C(Predicted)
Dichte
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO : 50 mg/mL (88.55 mM);Water : < 0.1 mg/mL (insoluble)
Aggregatzustand
Solid
pka
14.10±0.50(Predicted)
Farbe
White to off-white
InChIKey
DETOMBLLEOZTMZ-UHFFFAOYSA-N
SMILES
N1(CC2=CNN=C2)C2=C(C(C)=C(CN3CCC(NC4N=CN=C5SC(CC(F)(F)F)=CC5=4)CC3)C=C2)C=C1C#N

Sicherheit

MI-503 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

MI-503 is used in the pharmacological inhibition of menin-MLL interaction that blocks progression of MLL leukemia in vivo.

Biochem/physiol Actions

MI-503 is a highly potent menin-MLL interaction inhibitor (cell-free IC50 = 14.7 nM against 1 nM FITC-MLL(4-13) peptide; cellular IC50 = 220 nM using HEK293 MLL-AF9 fusion transfectants) that targets menin MLL-binding site with high affinity (KD = 9.3 nM by ITC). MI-503 selectively inhibits mixed lineage leukemia (MLL) oncogenic fusion-driven cancer progression in cultures (GI50 from 250 to 570 nM; GI50 >5 μM against cells without MLL gene translocation) and is efficacious against human MLL leukemia MV4;  tumor growth in mice in vivo (by 80-100%; 60 mg/kg/day i.p.) with good pharmacokinetic properties, oral bioavailability (73% post 30 mg/kg p.o.), and no adverse effects to the animals.

MI-503 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MI-503 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 82)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Chuchang Biotech Co., Ltd.
+undefined15623860702
 info@chuchangbiotech.com China 116 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32951 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38596 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028
 kathy@hbyinsheng.com China 3512 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 10986 58
Nanjing Bicbiotechnology Co., Ltd 		+86-2552131256 +86-18251840740
 sales@bicbiotech.com China 5994 58
  • mi503
  • mi-503
  • 1-((1H-Pyrazol-4-yl)methyl)-4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-
  • MI503;MI 503
  • CS-1946
  • 1H-Indole-2-carbonitrile, 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
  • 1-((1H-Pyrazol-4-yl)methyl)-4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile
  • Inhibitor,MI503,inhibit,MI 503,MI-503,Epigenetic Reader Domain
  • M1-503
  • 1857417-13-0
  • 857417-13-0
  • C28H27F3N8S
Copyright 2019 ? ChemicalBook. All rights reserved