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    AZ191

    AZ191 Struktur
    1594092-37-1
    CAS-Nr.
    1594092-37-1
    Englisch Name:
    AZ191
    Synonyma:
    AZ191;CS-1824;AZ-191;AZ 191;AZ191, 10 mM in DMSO;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine;2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-;[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine;Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191
    CBNumber:
    CB22716123
    Summenformel:
    C24H27N7O
    Molgewicht:
    429.52
    MOL-Datei:
    1594092-37-1.mol

    AZ191 Eigenschaften

    Siedepunkt:
    705.3±70.0 °C(Predicted)
    Dichte
    1.29±0.1 g/cm3(Predicted)
    storage temp. 
    Keep in dark place,Sealed in dry,Store in freezer, under -20°C
    L?slichkeit
    DMSO: soluble10mg/mL, clear
    Aggregatzustand
    powder
    pka
    7.76±0.42(Predicted)
    Farbe
    white to yellow to light brown
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    WGK Germany  3
    Bildanzeige (GHS) GHS hazard pictograms
    Alarmwort Achtung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H227 Combustible liquid Flammable liquids Category 4 Warnung P210, P280, P370+P378, P403+P235,P501
    H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
    Sicherheit
    P210 Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
    P264 Nach Gebrauch gründlich waschen.
    P264 Nach Gebrauch gründlich waschen.
    P270 Bei Gebrauch nicht essen, trinken oder rauchen.
    P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
    P370+P378 Bei Brand: zum L?schen verwenden.
    P403+P235 An einem gut belüfteten Ort aufbewahren. Kühl halten.
    P405 Unter Verschluss aufbewahren.
    P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

    AZ191 Chemische Eigenschaften,Einsatz,Produktion Methoden

    Enzyminhibitor

    This potent and selective DYRK inhibitor (FW = 429.53 g/mol), also systematically named N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4- (1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, selectively targets DYRK1B, a Dual specificity tyrosine-phosphorylation-regulated kinase, with an IC50 value of 17 nM, or about 5x and 110x higher affinity than for DYRK1A and DYRK2. AZ191 is effective both in vitro and in cells. DYRK1B has also been proposed to promote the turnover of Cyclin D1, a key regulator of mammalian G1-S-phase transitions. Cyclin D1 is phosphorylated on Thr-286 by GSK3β (or glycogen synthase kinase 3β), thereby promoting its degradation.

    AZ191 Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    AZ191 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 94)Lieferanten
    Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
    ATK CHEMICAL COMPANY LIMITED
    +undefined-21-51877795
    ivan@atkchemical.com China 33024 60
    career henan chemical co
    +86-0371-86658258 +8613203830695
    sales@coreychem.com China 29857 58
    TargetMol Chemicals Inc.
    +1-781-999-5354 +1-00000000000
    marketing@targetmol.com United States 32265 58
    InvivoChem
    +1-708-310-1919 +1-13798911105
    sales@invivochem.cn United States 6391 58
    Nantong HI-FUTURE Biology Co., Ltd.
    +undefined18051384581
    sales@chemhifuture.com China 3135 58
    TargetMol Chemicals Inc.

    support@targetmol.com United States 38659 58
    ShenZhen Trendseen Biological Technology Co.,Ltd.
    13417589054
    trendseenbio@gmail.com China 11681 58
    LEAPCHEM CO., LTD.
    +86-852-30606658
    market18@leapchem.com China 43340 58
    Henan Fengda Chemical Co., Ltd
    +86-371-86557731 +86-13613820652
    info@fdachem.com China 20232 58
    Aladdin Scientific

    tp@aladdinsci.com United States 57505 58

    • N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191
    • [2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine
    • AZ191
    • AZ-191;AZ 191
    • CS-1824
    • N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
    • 2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-
    • Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK
    • AZ191, 10 mM in DMSO
    • 1594092-37-1
    • C24H27N7O
    • Inhibitors
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