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MTEP

MTEP Struktur
1186195-60-7
CAS-Nr.
1186195-60-7
Englisch Name:
MTEP
Synonyma:
MTEP HCl;3-((2-Methyl-1;MTEP hydrochloride, mGlu5 antagonist;MTEP hydrochloride (mM/ml), mGlu5 antagonist;3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride;3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1);3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP;Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride;3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
CBNumber:
CB22628565
Summenformel:
C11H9ClN2S
Molgewicht:
236.72056
MOL-Datei:
1186195-60-7.mol

MTEP Eigenschaften

Schmelzpunkt:
154-156℃ (isopropanol )
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
crystalline solid
Farbe
Light cream

Sicherheit

MTEP Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50 = 110 nM). MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression. It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection. Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.

Verwenden

MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.

MTEP Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


MTEP Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 38)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
info@yuhaochemical.com China 9387 52
Haoyuan Chemexpress Co., Ltd. 021-58950125
info@chemexpress.com China 7552 61
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216
info@yuhaochemical.com China 2028 58
AdooQ Bioscience CHINA 025-58849295 18951903616;
info@adooq.cn China 2990 60
LETOPHARM LIMITED +86-21-5821 5861
sales@letopharm.com China 2384 58

1186195-60-7()Verwandte Suche:


  • 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
  • 3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1)
  • MTEP HCl
  • 3-((2-Methyl-1
  • 3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP
  • 3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride
  • Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride
  • MTEP hydrochloride (mM/ml), mGlu5 antagonist
  • MTEP hydrochloride, mGlu5 antagonist
  • 1186195-60-7
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