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JGB1741

JGB1741 Struktur
1256375-38-8
CAS-Nr.
1256375-38-8
Englisch Name:
JGB1741
Synonyma:
JGB1741;CRTIXRJWHKMWCH-STBIYBPSSA-N;(E)-N-Benzyl-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide;Benzo[b]thiophene-3-carboxamide, 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-
CBNumber:
CB22591386
Summenformel:
C27H24N2O2S
Molgewicht:
440.56
MOL-Datei:
1256375-38-8.mol

JGB1741 Eigenschaften

Schmelzpunkt:
242-243 °C
Siedepunkt:
700.2±60.0 °C(Predicted)
Dichte
1.28±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
≤0.2mg/ml in DMSO;0.14mg/ml in dimethyl formamide
Aggregatzustand
crystalline solid
pka
8.00±0.50(Predicted)
Farbe
Light yellow to yellow

Sicherheit

JGB1741 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to longevity, cancer, gene regulation, energy homeostasis, and apoptosis. JGB1741 is a small molecule inhibitor of SIRT1 with an IC50 value of 15 μM in a cell-free assay. It shows relatively weak inhibition for SIRT2 and SIRT3 with IC50 values greater than 100 μM. JGB1741 inhibits metastatic breast cancer MDA-MB 231 cell proliferation with an IC50 value of 512 nM in a cell-based assay and dose-dependently increases p53 acetylation and p53-mediated apoptosis in these cells.

JGB1741 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

JGB1741 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 27)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772
 huahero21@sina.com China 568 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8140 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761
 486064515@qq.com China 4492 58
Bide Pharmatech Ltd. 400-1647117 13681763483
 product02@bidepharm.com China 62075 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24644 58
RD International Technology Co., Limited 18024082417
 market@ubiochem.com China 9266 58
ApexBio Technology --
 sales@apexbt.com United States 6251 58
  • JGB1741
  • Benzo[b]thiophene-3-carboxamide, 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-
  • CRTIXRJWHKMWCH-STBIYBPSSA-N
  • (E)-N-Benzyl-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
  • 1256375-38-8
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