(±)11(12)-EET
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- CAS-Nr.
- 123931-40-8
- Englisch Name:
- (±)11(12)-EET
- Synonyma:
- 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100 mug/mL in ethanol, >=95%;5,8-Decadienoic acid, 10-[(2S,3R)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-, (5Z,8Z)-
- CBNumber:
- CB22589778
- Summenformel:
- C20H32O3
- Molgewicht:
- 320.47
- MOL-Datei:
- 123931-40-8.mol
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(±)11(12)-EET Eigenschaften
- Siedepunkt:
- 461.8±33.0 °C(Predicted)
- Dichte
- 0.983±0.06 g/cm3(Predicted)
- Flammpunkt:
- 9℃
- storage temp.
- -20°C
- L?slichkeit
- DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml
- pka
- 4.75±0.10(Predicted)
- Aggregatzustand
- Liquid
- Farbe
- Colorless to light yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
F |
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| R-S?tze: |
11 |
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| S-S?tze: |
7-16 |
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| RIDADR |
UN1170 - class 3 - PG 2 - Ethanol, solution |
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| WGK Germany |
1 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(±)11(12)-EET Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET has been shown, along with 8(9)-EET , to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells. It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM. 11(12)-EET (50 μg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties.
(±)11(12)-EET Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(±)11(12)-EET Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 16)Lieferanten
123931-40-8()Verwandte Suche:
3β-Hydroxyurs-12-en-28-sure
21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-
- 5,8-Decadienoic acid, 10-[(2S,3R)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-, (5Z,8Z)-
- 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100 mug/mL in ethanol, >=95%
- 123931-40-8
