Febuxostat-d9
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- CAS-Nr.
- 1246819-50-0
- Englisch Name:
- Febuxostat-d9
- Synonyma:
- TMX 67-d9;TEI 6720-d9;Febuxostat-d;Febuxostat-d9;[2H9]-Febuxostat;Dapagliflozin Impurity 138;Febuxostat-d9 (2-methylpropoxy-d9);2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid;2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid;2-(3-Cyano-4-(2-(methyl-d3)propoxy-1,1,2,3,3,3-d6)phenyl)-4-methylthiazole-5-carboxylic acid
- CBNumber:
- CB22508843
- Summenformel:
- C16H16N2O3S
- Molgewicht:
- 316.37484
- MOL-Datei:
- 1246819-50-0.mol
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Febuxostat-d9 Eigenschaften
- Schmelzpunkt:
- >201°C (dec.)
- storage temp.
- Refrigerator
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Febuxostat-d9 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Febuxostat-d
9 is intended for use as an internal standard for the quantification of febuxostat by GC- or LC-MS. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC
50s = 1.4, 1.8, and 2.2 nM, respectively). It is 10-30 times more potent than the hypoxanthine analog allopurinol (; K
is = 0.7 nM and 0.7 μM, respectively). Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED
50 = 1.5 mg/kg). It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing
trans fatty acids when administered at a dose of 1 mg/kg per day. Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE). Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.
Verwenden
Febuxostat-d9 is a Labeled compound, intended for use as an internal standard for the quantification of Febuxostat by GC- or LC-mass spectrometry.
Febuxostat-d9 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Febuxostat-d9 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 56)Lieferanten
1246819-50-0()Verwandte Suche:
- Febuxostat-d9
- 2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid
- 2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
- TEI 6720-d9
- TMX 67-d9
- [2H9]-Febuxostat
- Febuxostat-d9 (2-methylpropoxy-d9)
- Febuxostat D9Q: What is
Febuxostat D9 Q: What is the CAS Number of
Febuxostat D9 Q: What is the storage condition of
Febuxostat D9 Q: What are the applications of
Febuxostat D9
- Dapagliflozin Impurity 138
- Febuxostat-d
- 2-(3-Cyano-4-(2-(methyl-d3)propoxy-1,1,2,3,3,3-d6)phenyl)-4-methylthiazole-5-carboxylic acid
- 5-Thiazolecarboxylic acid, 2-[3-cyano-4-[2-(methyl-d3)propoxy-1,1,2,3,3,3-d6]phenyl]-4-methyl-
- 1246819-50-0
- C16H7D9N2O3S
- Inhibitors
- Intermediates & Fine Chemicals
- Isotope Labelled Compounds
- Pharmaceuticals
- Heterocycles
