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OSU-03012

OSU-03012 Struktur
742112-33-0
CAS-Nr.
742112-33-0
Englisch Name:
OSU-03012
Synonyma:
AR-12;CS-1848;N/AAR-12;OSU-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;PDK1 inhibitor AR-12;N/AAR-12; OSU03012; OSU 03012;Osu-03012|||Osu 03012|||AR-12
CBNumber:
CB22501006
Summenformel:
C26H19F3N4O
Molgewicht:
460.45
MOL-Datei:
742112-33-0.mol

OSU-03012 Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Aggregatzustand
solid
Farbe
White to off-white
CAS Datenbank
742112-33-0

Sicherheit

OSU-03012 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC50 value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

Verwenden

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

Definition

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

OSU-03012 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


OSU-03012 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 129)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32951 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29884 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 965 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32112 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22883 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894
shawn@hirisunpharm.com CHINA 9911 58

  • OSU-03012, >=98%
  • OSU-03012 (AR-12)
  • 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide
  • 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012
  • N/AAR-12
  • OSU-03012
  • 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide
  • OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012
  • CS-1848
  • N/AAR-12; OSU03012; OSU 03012
  • Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-
  • OSU-03012 USP/EP/BP
  • AR-12
  • Osu-03012|||Osu 03012|||AR-12
  • PDK1 inhibitor AR-12
  • 742112-33-0
  • C26H19F3N4O
  • Inhibitors
  • Inhibitor of phosphoinositide-dependent kinase-1.
  • Akt
  • mTOR
  • PI3K
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