lurasidone
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- CAS-Nr.
- 367514-87-2
- Englisch Name:
- lurasidone
- Synonyma:
- CS-327;urasidone;lurasidone;Lurasindone;Lurasidone Base;Lurasidone, >=98%;Lurasidone (SM13496);lurasidone USP/EP/BP;Lurasidone Free base;TIANFU-CHEM - lurasidone
- CBNumber:
- CB22498821
- Summenformel:
- C28H36N4O2S
- Molgewicht:
- 492.68
- MOL-Datei:
- 367514-87-2.mol
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lurasidone Eigenschaften
- Schmelzpunkt:
- 146-149°C
- Siedepunkt:
- 623.4±55.0 °C(Predicted)
- Dichte
- 1.273
- storage temp.
- -20°C Freezer
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- pka
- 8.41±0.50(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChIKey
- PQXKDMSYBGKCJA-CVTJIBDQSA-N
- SMILES
- C1(=O)[C@]2([H])[C@@]([H])([C@]3([H])C[C@@]2([H])CC3)C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(C2C3=C(SN=2)C=CC=C3)CC1
- CAS Datenbank
- 367514-87-2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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lurasidone Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The atypical antipsychotic lurasidone (also known as SM-13496) was
approved in the United States in 2010 as an oral agent for the treatment
of patients with schizophrenia. Lurasidone has potent affinity for D
2 (K
i= 1.7 nM)
and 5-HT
2A (K
i= 2.0 nM) receptors and acts as an antagonist at both
receptors. It is also a partial agonist at the 5-HT
1A receptor and,
unlike other atypical agents, is a potent antagonist at the 5-HT
7 receptor;
both of these activities are thought to confer beneficial cognitive properties.
Lurasidone is further differentiated by its lack of affinity for muscarinic
and histamine H
1 receptors and its weak affinity for the 5-HT
2C
receptor. Antagonism at H
1 and 5-HT
2C receptors has been implicated in
weight gain associated with atypical agents, while muscarinic receptor
antagonism is associated with cognitive deficits.
Definition
ChEBI: An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-m
thanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizoph
enia.
lurasidone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
lurasidone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 235)Lieferanten
- 4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione
- lurasidone
- (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
- Lurasidone (SM13496)
- (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione
- urasidone
- Lurasidone, >=98%
- Lurasidone Base
- (3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione
- CS-327
- 4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)-
- (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
- lurasidone USP/EP/BP
- TIANFU-CHEM - lurasidone
- SM13496; SM-13496; SM 13496
- Lurasidone Free base
- Lurasindone
- (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinylChemicalbook]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
- (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4
- Lurasidone
(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3- yl)piperazin-1-yl)methyl)
cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)- dione
- (1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3- yl)piperazin-1-yl]methyl}-cyclohexyl]methyl}-4- azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione
- 367514-87-2
- C28H36N4O2S
- Pharmaceutical intermediate
