Epinastine
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- CAS-Nr.
- 80012-43-7
- Englisch Name:
- Epinastine
- Synonyma:
- WAL801;CS-1366;EPINASTINE;ELESTAT;WAL801;Apinastine Base;EPINASTINE BASE;Epinastine (WAL801);Epinastine USP/EP/BP;Epinastine in methanol;9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine
- CBNumber:
- CB2230197
- Summenformel:
- C16H15N3
- Molgewicht:
- 249.31
- MOL-Datei:
- 80012-43-7.mol
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Epinastine Eigenschaften
- Schmelzpunkt:
- 205-208°
- Siedepunkt:
- 428.0±55.0 °C(Predicted)
- Dichte
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO : ≥ 50 mg/mL (200.55 mM);Water : < 0.1 mg/mL (insoluble)
- pka
- 11.2(at 25℃)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- CAS Datenbank
- 80012-43-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Epinastine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Epinastine hydrochloride, an orally active antihistaminic agent, was marketed in
Japan for the treatment of bronchial asthma, allergic rhinitis, urticaria, eczema,
dermatitis, and psoriasis vulgaris.Epinastine is one of the most effective
peripherally acting histamine H
1-receptor antagonists without sedative effects.In
addition, it exhibits potent anti-PAF and anti-LT activity which may also contribute
significantly to its antiallergic activity. Chronic epinastine has been reported to
effectively inhibit airway hyper-responsiveness in rats. Potent inhibitory effects of
epinastine on bronchoconstriction induced by histamine and bradykinin, but not by
other chemical mediators, has also been reported. Studies have indicated that there
are no significant differences in pharmacological properties among D-, L-, and
racemic epinastine.
Verwenden
Epinastine is antihistamine and mast cell stabilize that is used in eye drops for the treatment of allergic conjunctivitis.
Definition
ChEBI: A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Clinical Use
Epinastine is a potent, long-acting H1 antihistamine and an inhibitor of the release of
histamine and other transmitters from mast cells. It has some affinity for H2 receptors as well.
It is used as an eye drop for allergic conjunctivitis. It does not penetrate into the CNS and is
classified as a nonsedating antihistamine.
Epinastine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Epinastine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 160)Lieferanten
80012-43-7()Verwandte Suche:
- 3-amino-9,13b-dihydro-1h-dibenz[c,f]imidazo[1,5-a]azepine
- EPINASTINE
- EPINASTINE BASE
- 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine
- Apinastine Base
- 3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine
- CS-1366
- ELESTAT;WAL801
- WAL801
- 1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine, 9,13b-dihydro-
- Epinastine USP/EP/BP
- Epinastine (WAL801)
- EpinastineQ: What is
Epinastine Q: What is the CAS Number of
Epinastine Q: What is the storage condition of
Epinastine
- 9,13b-Dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
- Epinastine in methanol
- 2,4-diazatetracyclo[12.4.0.02,?.0?,12]octadeca-1(14),3,7(12),8,10,15,17-heptaen-3-amine
- 80012-43-7
- 80012-43-07
- C16H15N3
