Rocuronium bromide Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

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Verwenden

Aminosteroid, competitive neuromuscular blocker

Beschreibung

Rocuronium bromide is a short-acting nondepolarizing steroidal neuromuscular blocker introduced in the U.S.A as Zemuron and in the United Kingdom as Esmeron. k is indicated for use as an adjunct to general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Rocuroniurn bromide has a significantly more rapid onset than other intermediate acting neuromuscular blockers, comparable to succinylcholine but with a very stable cardiovascular profile and has an improved side effect profile. It has been reported that good to excellent intubation conditions were achieved only one minute after a bolus dose of 600μg/kg of rocuronium bromide. It has a short duration of action, therefore, is useful for rapid sequence intubation without unacceptable delays in the spontaneous recovery of neuromuscular function.

Definition

ChEBI: Rocuronium bromide is the organic bromide salt of a 5alpha androstane compound having 3alpha-hydroxy-, 17beta-acetoxy-, 2beta-morpholino- and 16beta-N-allyllyrrolidinium substituents. It has a role as a neuromuscular agent and a muscle relaxant. It is an organic bromide salt and a quaternary ammonium salt. It contains a rocuronium. It derives from a hydride of a 5alpha-androstane.

Biologische Funktion

Rocuronium bromide (Zemuron) is a recently approved amino steroid neuromuscular blocking agent. It has a rapid onset of action (1 minute), but its duration of action is intermediate (55 minutes), about that of vecuronium. On rare occasions, it may release histamine and cause cardiac irregularities. Rapacuronium bromide (Raplon) is the most recent neuromuscular blocking agent approved by the United States Food and Drug Administration (FDA). It is an analogue of vecuronium and is thus categorized as an amino steroid. It has a rapid onset of action (1.5 minutes) and a short to intermediate duration of action (20 minutes).This makes it a suitable alternative to mivacurium or succinylcholine for short procedures. It is eliminated mainly by the liver.Adverse effects are dose dependent; they include tachycardia, hypotension, and bronchospasm. These effects may be related to the ability of the drug to release a small amount of histamine.

Rocuronium bromide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Rocuronium bromide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Jinan Good Medical Technology Co.,Ltd	+86-53155562571 +86-008613553167512	13553167512@139.com	China	23	58
Biopole Pharmatech Co., Ltd.	+8615151475053	biopole@163.com	China	37	58
Eaglech（shanghai）Pharmaceutical Co., Ltd	+86-2160290089 +86-13884467586	eagpharm@gmail.com	China	94	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8804	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5887	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20259	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29792	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21632	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60

119302-91-9()Verwandte Suche:

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• ROCURONIUM BROMIDE
• Org-9426
• [3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl] acetate bromide
• ROCURONIUN BROMIDE
• 1-[17B-(acetyloxy)-3a-hydroxy2B-(4-morpholinyl)-5a -androstan-16B-yl]-1-(2-propenyl)pyrrolidinium bromide
• 1-[(2,3a,5a,16,17)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Bromide
• 1-[(2β，3α，5α，16β，17β)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)andrcstan-16-y1]-1-propenylpyrrolidinium bromide
• Esmeron：Zemuron
• Eslax
• Rocuronium Bromide (250 mg)
• RocuroniuM BroMide IsoMers
• 1-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-14-(acetyloxy)-5-hydroxy-2,15-diMethyl-4-(Morpholin-4-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-(prop-2-en-1-yl)pyrrolidin-1-iuM
• 1-[(2β,3α,5α,16β,17β)-17-(Acetyloxy)-3-hydroxy-2-(4-Morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidiniuM BroMide
• 1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetoxy-3-hydroxy-10,13-diMethyl-2-Morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidin-1-iuM broMide
• RocuroniuM BroMideAPI
• Pyrrolidinium, 1-[(2β,3α,5α,16β,17β)-17-(acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)-, bromide
• Rocuronium hydrobromide
• 1-[17β-(Acetyloxy)-3α-hydroxy-2β-(morpholin-4-yl)-5α-androstan-16β-yl]-1-(prop-2-enyl)pyrrolidinium bromide
• Rocuronium bromide CRS
• Rocuronium for peak identification CRS
• Rocuronium Bromide >
• ORG 9426 (Bromide)
• Rocuronium dibromide
• Rocuronium bromide USP/EP/BP
• Rocuronium Bromide Crude
• Rocuronium bromide Impurity 47
• Rocuronium Bromide (ORG 9426 Bromide)
• Rocuronium for peak identification (Y0000527)
• Rocuronium Bromide (COLD SHIPMENT REQUIRED) (1604905)
• 1-[(2b,3a,5a,16b,17b)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Bromide
• Esmeron
• Zemuron
• Rocuronium Bromide／1-[17B-(acetyloxy)-3a-hydroxy2B-(4-morpholinyl)-5a-androstan-16B-yl]-1-(2-propenyl)pyrrolidinium bromide
• 1-[17B-(acetyloxy)-3a-hydroxy-2B-(4-morpholinyl)-
• Rocuronium Bromide USP/IP/PH.Eur
• 1-[17β-(acetyloxy)-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium bromide
• Rocuronium bromide, 10 mM in DMSO
• 119302-91-9
• 19302-91-9
• 119032-86-2
• C34H57NO4
• C32H53BrNO4
• C32H53N2O4Br
• C32H53BrN2O4
• BrC32H53N2O4
• Heterocycles
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• Steroid and Hormone
• Acetylcholine receptor
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• 119302-91-9
• API