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Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Struktur
160844-75-7
CAS-Nr.
160844-75-7
Englisch Name:
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Synonyma:
2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester;Febuxostat Ethyl Ester;Febuxostat-7;FEBUXOSTAT INT N-1;Non-Bust Impurity 23;Febuxostat Impurities3;ethyl ester of febuxostat;Febuxostat Ethyl Ester Impurity;ethyl 2-(3-cyano-4-isobutoxyphenyl);2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Me
CBNumber:
CB22129451
Summenformel:
C18H20N2O3S
Molgewicht:
344.43
MOL-Datei:
160844-75-7.mol

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Eigenschaften

Schmelzpunkt:
176 °C
Siedepunkt:
497.1±55.0 °C(Predicted)
Dichte
1.22
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
Aggregatzustand
Solid
pka
1.02±0.10(Predicted)
Farbe
White to Off-White
InChI
InChI=1S/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3
InChIKey
OGAZOYHQFBSRMC-UHFFFAOYSA-N
SMILES
S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C#N)=C1
CAS Datenbank
160844-75-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2934.10.2000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P321 Besondere Behandlung
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P362 Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White crystalline powder

Verwenden

Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Synthese

CarboxylatePotassium carbonate (300 g, 2.17 mol) and isobutyl bromide (142.7 g, 1.041 mol) were added to a solution of ethyl-2-(3-cyano-4-hydroxyphenyl)-4-methyl-5-thiazole carboxylate (100 g, 0.347 mol) in dimethylformamide (300 mL), and the reaction mixture was heated at a temperature of about 75°C for about 8 hours. After completion of the reaction, the reaction mixture was cooled to about 40°C, and water was added. The reaction mixture was further cooled to about 0°C and stirred for about 1 hour. The solid thus obtained was filtered, washed with water, and dried to give Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate. (Yield: 11 lg, 92.9%) Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

5-iodo-2-isobutoxybenzonitrile ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate 5-bromo-2-isobutoxy benzonitirle 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide (3-cyano-4-isobutoxyphenyl)boronic acid Febuxostat Impurity 6 ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Ethyl 4-methyl-5-thiazoleactate Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 5-Bromo-2-fluorobenzonitrile 1-Brom-2-methylpropan

Downstream Produkte

Febuxostat

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 418)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
+86-18616643091 +86-18616643091
 info@rochipharma.com China 246 58
JUYE XIANDAI fine chemistry Co.,Ltd
+86-18958038633; +8618958038633
 tony@sdhypharma.com China 64 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-15536356810
 1022@dideu.com China 3882 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12834 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
 peter@yan-xi.com China 5857 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 10986 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858
 daisy@anhuiruihan.com China 973 58
ShenZhen H&D Pharmaceutical Technology Co., LTD 		+8618627948422
 sale@hdimpurity.com China 3389 58
HEBEI BRANT PHARMACEUTICAL CO.,LTD 		+86-311-84455288 +86-18832137600
 rice@brantpharm.com China 17 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60

160844-75-7()Verwandte Suche:

  • 5-Thiazolecarboxylicacid, 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester
  • 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
  • ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl
  • Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
  • Ethyl> 2-(3-cyano-4-isobutoxyphenyl)-4-Methyl-5-th
  • 5-carboxylato-2-[3-cyano-4-(2-Methylpropoxy)phenyl]-1-ethyl-4-Methyl-1H-1$l^{4},3-thiazol-1-yl
  • ethyl ester of febuxostat
  • 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Me
  • Febuxostat Ethyl Ester Impurity
  • Febuxostat Impurity 15/Febuxostat Ethyl Ester/Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
  • Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazol
  • Febuxostat-7
  • 2[3-Cyano-4-(2-methyl propoxy)phenyl]4-methyl-5-thiazole carboxylic acid ethyl ester (CPT)
  • ethyl 2-(3-cyano-4-isobutoxyphenyl)
  • Non-Bust Impurity 23
  • 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester
  • FEBUXOSTAT INT N-1
  • 2-[3-CYANO-4-(2-METHYLPROPOXY)PHENYL]-4-METHYL-5-THIAZOLECARBOXYLIC ACID ETHYL
  • Febuxostat intermediates，Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4- methyl-5-thiazolecarboxylate
  • 2-(4-isobutoxyphenyl)-3-carboxylate)4-methyl-1,3- thiazole-5- carboxylate acid( Febuxostat dicarboxylic acid impurity)
  • Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarbo...
  • Febuxostat Impurities3
  • 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl esterQ: What is 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the CAS Number of 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the storage condition of 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester
  • Febuxostat Ethyl Ester
  • 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester
  • Ethyl 2-(3- cyano -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate
  • Ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate
  • Ethyl 2-(3-cyno-4-isobutoxyphenyl)-4-methyl-5- thiazolecarboxylate
  • 2-(4-ISOBUTOXYPHENYL)-3-CARBOXYLATE)4-METHYL-1,3- THIAZOLE-5-
  • Febuxostat Ethyl Ester Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate
  • 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
  • 160844-75-7
  • 161797-01-2
  • Febuxostat Intermediates
  • Febuxostat intermediate
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