Cyclosporin C
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- CAS-Nr.
- 59787-61-0
- Englisch Name:
- Cyclosporin C
- Synonyma:
- CL246;WF-3484;CS-2545;CS-2546;CYCLOSPORIN C;Thr2-cyclosporine;Cyclosporin C, >=95%;Cyclosporine IMpurity-C;Cyclosporin Impurity C;Cyclosporine Impurity 3
- CBNumber:
- CB2153074
- Summenformel:
- C62H111N11O13
- Molgewicht:
- 1218.61
- MOL-Datei:
- 59787-61-0.mol
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Cyclosporin C Eigenschaften
- Schmelzpunkt:
- 144-1460C
- alpha
- D20 -255° (c = 0.5 in chloroform); D20 -182° (c = 0.5 in methanol)
- Siedepunkt:
- 1316.0±65.0 °C(Predicted)
- Dichte
- 1.033±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- DMSO: ≥10mg/mL
- pka
- 13.06±0.70(Predicted)
- Aggregatzustand
- Colorless to off-white crystalline solid.
- Farbe
- White to Off-White
- InChIKey
- JTOKYIBTLUQVQV-PCACHRFWSA-N
- CAS Datenbank
- 59787-61-0
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H350 |
Kann Krebs verursachen. |
Karzinogenit?t |
Kategorie 1A |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
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| H362 |
Kann S?uglinge über die Muttermilch sch?digen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
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P201, P260, P263, P264, P270,P308+P313 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt w?hrend der Schwangerschaft /und der Stillzeit vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Cyclosporin C Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cyclosporin C is a fungal metabolite that has been found in
T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. It is active against isolates of
B. cinerea,
A. niger, and
Alternaria,
Mucor, and
Penicillium species (MICs = 0.1-5 μg/ml). Cyclosporin C (15 μg/ml) inhibits vaccinia virus replication in infected BSC40 cells by 98.82%. It inhibits lymphocyte proliferation induced by the mitogens concanavalin A (ConA; ), phytohemagglutinin L (PHA), and pokeweed mitogen (PWM), as well as proliferation induced by alloantigen in mixed lymphocyte culture when used at a concentration of 100 ng/ml. Cyclosporin C (100 ng/ml) inhibits the local graft
versus host (GVH) reaction in mice receiving splenocyte grafts.
Chemische Eigenschaften
White Solid
Verwenden
Cyclosporin C is a minor analogue of the cyclosporin complex produced by a number of fungal species, including Trichoderma, Tolypocladium, Fusarium, Nectria and Acremonium. Cyclosporin C possesses immunosuppressant activity but has been much less extensively investigated than the major analogue, cyclosporin A.
Cyclosporin C Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cyclosporin C Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 202)Lieferanten
59787-61-0()Verwandte Suche:
Kresoxim-methyl
Hexamethylphosphorsaeuretriamid
Methylacrylat
Methylthenoat
Methyl-4-hydroxybenzoat
(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo (1,2,3-gh: 3'2',1'-1m)pyrrolo(3,4-j)-(1,7)benzodiazonin-1-on, (9 alpha,10 beta, 11 beta, 13 alpha)-
Thiophanat-methyl
alpha-Toluolsulfonylfluorid
Cyclosporin A
(R)-(-)-2-Amino-3-methyl-1-butanol
Dimethylsulfon
Bensulfuron methyl
Valinomycin
Methyl
Parathion-methyl (ISO)
Brommethan
CYCLOSPORINE
- CYCLOSPORIN C
- Thr2-cyclosporine
- Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-threonyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Thr-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
- WF-3484
- 7-L-Threoninecyclosporin A
- Cyclosporine IMpurity-C
- 7-L-Threoninecyclosporin A, WF 3484
- 7-Threonine-cyclosporin A
- Cyclosporin C, >=95%
- Cyclosporine C/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-threonyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- 30-(1-hydroxyethyl)-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriaconta
- CS-2545
- CS-2546
- cyclo-[MeBmt-Thr-Sar-MeLeu-Val-MeLeu-Ala-D-Ala-MeLeu-MeLeu-MeVal]
- Cyclosporine EP Impurity C
- CL246
- Cyclosporin Impurity C
- Cyclosporin Impurity 3(Cyclosporin C)
- Cyclosporin A, 7-L-threonine-
- Cyclosporine Impurity 3
- (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-Hydroxy-2-methylhex-4-en-1-yl)-30-((R)-1-hydroxyethyl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
- (3R,6S,9S,12R,15R,18S,21R,24S,30R,33S)-30-(1-Hydroxyethyl)-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1
- (3R,6S,9S,12R,15R,18S,21R,24S,30R,33S)-30-(1-Hydroxyethyl)-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
- Cyclosporin C, EvoPure?
- (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-30-[(1R)-1-hydroxyethyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
- 59787-61-0
- 69787-61-0
- 59767-61-0
- C62H111N11O13
- Intermediates & Fine Chemicals
- Peptides
- Pharmaceuticals
- ACTIVE PHARMACEUTICAL INGREDIENTS
