Methyl 5-bromo-2-chloropyridine-3-carboxylate
|
|
|
- CAS-Nr.
- 78686-79-0
- Englisch Name:
- Methyl 5-bromo-2-chloropyridine-3-carboxylate
- Synonyma:
- METHYL 5-BROMO-2-CHLORONICOTINATE;methyl 2-chloro-5-bromonicotinate;Methyl5-Bromo-2-chloronicotinate>Methyl 5-bromo-2-chloronicotinate 98%;Methyl 5-broMo-2-chloronicotinate, 95+%;2-Chloro-5-bromonicotinic acid methyl ester;5-BROMO-2-CHLORONICOTINIC ACID METHYL ESTER;Methyl 5-bromo-2-chloropyridine-3-carboxlate;methyl 5-bromo-2-chloro-3-pyridinecarboxylate;METHYL 5-BROMO-2-CHLOROPYRIDINE-3-CARBOXYLATE
- CBNumber:
- CB2150790
- Summenformel:
- C7H5BrClNO2
- Molgewicht:
- 250.48
- MOL-Datei:
- 78686-79-0.mol
|
Methyl 5-bromo-2-chloropyridine-3-carboxylate Eigenschaften
- Schmelzpunkt:
- 50-52°C
- Siedepunkt:
- 275.6±35.0 °C(Predicted)
- Dichte
- 1.684±0.06 g/cm3(Predicted)
- Flammpunkt:
- >110 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- soluble in Methanol
- pka
- -3.78±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Light yellow to Light orange
- Sensitive
- Light, Air & Moisture Sensitive
- InChIKey
- MOMQDEDQGJAKII-UHFFFAOYSA-N
- CAS Datenbank
- 78686-79-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,Xn |
|
|
| R-S?tze: |
22 |
|
|
| WGK Germany |
3 |
|
|
| HazardClass |
IRRITANT |
|
|
| HS Code |
2933399990 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P330 |
Mund ausspülen. |
|
Methyl 5-bromo-2-chloropyridine-3-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
Methyl 5-bromo-2-chloropyridine-3-carboxylate is prepared by the reaction of 5-Bromo-2-chloronicotinic acid and Methanol. The specific synthesis steps are as follows:
To 0.5 L flask charged with 5-Bromo-2-chloronicotinic acid (25.0 g, 106.4 mmol) in MeOH (250 mL) was added H2SO4(5 mL). The mixture was heated to 60° C., stirred for 1.5 day. LC-MS indicated full conversion of starting material at this time. The reaction was cooled to RT and the volatile components removed in vacuo. The crude residue was dissolved in EtOAc (300 mL), quenched with sat. aqueous Na(HCO3)2(200 mL). The organic layer was separated, washed with brine, dried over MgSO4and concentrated to afford the compound, methyl-5-bromo-2-chloronicotinate, as a while solid (quantitative yield). LC-MS (M+H)=250.1.
Methyl 5-bromo-2-chloropyridine-3-carboxylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methyl 5-bromo-2-chloropyridine-3-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 214)Lieferanten
78686-79-0()Verwandte Suche:
- METHYL 5-BROMO-2-CHLOROPYRIDINE-3-CARBOXYLATE
- Methyl 5-broMo-2-chloronicotinate, 95+%
- 5-Bromo-2-chloropyridine-3-carboxylic acid methyl ester
- Methyl 5-bromo-2-chloropyridine-3-carboxlate
- Methyl 5-bromo-2-chloronicotinate 98%
- methyl 5-bromo-2-chloro-3-pyridinecarboxylate
- 5-BROMO-2-CHLORONICOTINIC ACID METHYL ESTER
- Methyl 5-bromo-2-chloropyridine-3-carboxylate, 5-Bromo-2-chloro-3-(methoxycarbonyl)pyridine
- methyl 2-chloro-5-bromonicotinate
- 2-Chloro-5-bromonicotinic acid methyl ester
- Methyl5-Bromo-2-chloronicotinate>
- 3-Pyridinecarboxylic acid, 5-bromo-2-chloro-, methyl ester
- 5-Bromo-2-chloro-3-pyridinecarboxylic Acid Methyl Ester
- Methyl 5-bromo-2-chloropyridine-3-carboxylate ISO 9001：2015 REACH
- METHYL 5-BROMO-2-CHLORONICOTINATE
- 78686-79-0
- C7H5BrClNO2
- Esters
- Pyridine
- blocks
- Bromides
- Carboxes
- Pyridines
