Methylene boldenone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC₅₀ = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC₅₀ = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC₅₀ = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC₅₀ = 2.7 μM) and T47D breast cancer cells (EC₅₀s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.

Chemische Eigenschaften

Off-White Solid

Verwenden

A metabolite of Exemestane; exerts biological effects as an androgen.

Methylene boldenone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Methylene boldenone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8615195660023	sales@senfeida.com	China	23046	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11922	58
QUALITY CONTROL SOLUTIONS LTD.	0755-66853366; 13670046396	ORDERS@QCSRM.COM	China	24342	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9679	58
Cato Research Chemicals Inc.	020-81960175	min.he@cato-chem.com	China	1955	55

122370-91-6()Verwandte Suche:

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• METHYLENE BOLDENONE
• (17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
• (17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
• 17--Hydroxy Exemestane
• (17β)-
• 17β-Hydroxy ExeMestane SulfaMate
• Exemestane 17β-Hydroxy Impurity
• Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-
• 17β-Hydroxy Exemestane
• (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
• Exemestane Impurity 23 (Exemestane EP Impurity H)
• 17beta-Hydroxy-6-methylideneandrosta-1,4-dien-3-one (17beta-Hydroxyexemestane)
• 122370-91-6
• Intermediates & Fine Chemicals
• Metabolites & Impurities
• Pharmaceuticals
• Steroids