4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene
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- CAS-Nr.
- 112241-19-7
- Englisch Name:
- 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene
- Synonyma:
- 4-Succinimidyloxycarbonyl-α-Methyl-α-(2-Pyridyldithio)toluene;4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene;2,5-Dioxopyrrolidin-1-yl 4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoate;2,5-dioxopyrrolidin-1-yl 4-(1-(pyridin-2-yldisulfaneyl)ethyl)benzoate;Benzoic acid, 4-[1-(2-pyridinyldithio)ethyl]-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber:
- CB21374227
- Summenformel:
- C18H16N2O4S2
- Molgewicht:
- 388.46
- MOL-Datei:
- 112241-19-7.mol
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4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- Solid
- Farbe
- Light yellow to yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
SMPT is a heterobifunctional sulfhydryl- and amine-reactive cross-linker. SMPT is used often for conjugating a toxin molecule to a monoclonal antibody directed against a cell-surface antigen. These immunotoxins produced with SMPT are highly potent as the cleavable disulfide imparts increased cytotoxicity compared to conjugates without a cleavable bond, such as those produced with SPDP. Also, next to the pyridine-2-thione in the spacer arm are a benzene ring and a methyl group adjacent to a carbon that hinders the disulfide bond, allowing exceptional conjugate stability in vivo. SMPT has the added benefit of being more stable to hydrolysis in aqueous solutions than other NHS cross-linkers.
4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 29)Lieferanten
- 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene
- Benzoic acid, 4-[1-(2-pyridinyldithio)ethyl]-, 2,5-dioxo-1-pyrrolidinyl ester
- 2,5-dioxopyrrolidin-1-yl 4-(1-(pyridin-2-yldisulfaneyl)ethyl)benzoate
- 2,5-Dioxopyrrolidin-1-yl 4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoate
- 4-Succinimidyloxycarbonyl-α-Methyl-α-(2-Pyridyldithio)toluene
- 112241-19-7
