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Docarpamine

Docarpamine Struktur
74639-40-0
CAS-Nr.
74639-40-0
Englisch Name:
Docarpamine
Synonyma:
TA 870;TA-8704;Tanadopa;Docarpamine;3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine;4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate;(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide;Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester;Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-;Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
CBNumber:
CB21178560
Summenformel:
C21H30N2O8S
Molgewicht:
470.54
MOL-Datei:
74639-40-0.mol

Docarpamine Eigenschaften

Schmelzpunkt:
85-90°; mp 105-108° (Nishiyama, 1992)
alpha 
D20 -15.6° (c = 2 in methanol)
Siedepunkt:
731.0±60.0 °C(Predicted)
Dichte
1.222±0.06 g/cm3(Predicted)
pka
14.51±0.46(Predicted)

Sicherheit

Toxizit?t LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992)

Docarpamine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA1) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.

Verwenden

Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.

Docarpamine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Docarpamine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 11)Lieferanten
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SHANGHAI HOHANCE CHEMICAL CO.,LTD 021-31115312 18217084087
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Hubei Shishun Biotechnology Co. Ltd 027-59223025 15107168801
 1718480011@qq.com China 9847 58
Hubei Guangao Biotechnology Co., Ltd 027-027-59223056 18162699093
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Hubei Qifei Pharmaceutical Chemical Co., Ltd 027-027-59322506 18071128681
 1438082200@qq.com China 9975 58
R.R Scientific, LLC. 15010167677
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Shaanxi Didu New Material Co., Ltd 029-029-63373950 15353716720
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Weifu (Shanghai) Pharmaceutical Technology Co., LTD 021-31115312 13917553503
 401919639@qq.com China 237 58
TLC Pharmaceutical Standards Ltd. 18012923235; 18012923235
 chinasales04@tlcstandards.com.cn China 4928 58
  • Docarpamine
  • Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester
  • Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-
  • TA 870
  • Tanadopa
  • (S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide
  • 3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine
  • TA-8704
  • Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
  • 4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate
  • 74639-40-0
  • C21H30N2O8S
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