GF109203X
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- CAS-Nr.
- 133052-90-1
- Englisch Name:
- GF109203X
- Synonyma:
- BIM 1;GO 6850;G 6850];CS-1080;Estorra;GF 109203X;GO 6850 HCL;GF-109203X HCL;RBT205 INHIBITOR;GF109203X Go-6850
- CBNumber:
- CB2103079
- Summenformel:
- C25H24N4O2
- Molgewicht:
- 412.48
- MOL-Datei:
- 133052-90-1.mol
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GF109203X Eigenschaften
- Schmelzpunkt:
- 280℃ (decomposition)
- Siedepunkt:
- 685.6±55.0 °C(Predicted)
- Dichte
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ~1 mg/mlsoluble
- Aggregatzustand
- Liquid
- pka
- 8.13±0.60(Predicted)
- Farbe
- Orange
- Wasserl?slichkeit
- Insoluble in water.
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
40-22 |
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| S-S?tze: |
36/37 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UX9590000 |
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| HS Code |
2925199590 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H350 |
Kann Krebs verursachen. |
Karzinogenit?t |
Kategorie 1A |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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GF109203X Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Verwenden
Bisindolylmaleimide is used as a highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3, used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals, very potent and selective inhibitor of protein kinase C.
Biologische Aktivit?t
Very potent and selective inhibitor of protein kinase C, selective for the α and β 1 isoforms (IC 50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μ M for α , β 1, δ , ε , and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC 50 values are 0.6, 4.6, and 33 μ M respectively). Potent antagonist at the 5-HT 3 receptor (K i = 29.5 nM). Anti-inflammatory in vivo . Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.
GF109203X Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GF109203X Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 169)Lieferanten
- Bisindolylmaleimide I (GF 109203X)
- InSolution? Bisindolylmaleimide I
- GO 6850
- GO 6850 HCL
- GF 109203X
- GF-109203X HCL
- GF109203X HYDROCHLORIDE
- BISINDOLYLMALEIMIDE
- BISINDOLYLMALEIMIDE I
- BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- BISINDOYLMALEIMIDE
- 2-(1-(3-DIMETHYLAMINOPROPYL)-INDOL-3-YL)-3-(INDOL-3-YL)MALEIMIDE
- 2-[1-(3-DIMETHYLAMINOPROPYL)-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)-MALEIMIDE
- 2-[1-(3-DIMETHYLAMINOPROPYL)-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE, HCL
- 3-[1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2 ,5-DIONE
- 3-(N-[DIMETHYLAMINO]PROPYL-3-INDOLYL)-4-(3-INDOLYL)MALEIMIDE
- BisindolylmaleimideGF 109203X
- Bisindolylmaleinimide
- 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide,hydrochloride
- 1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-
- Bisindolylmaleimide
2-(1-(3-Dimethylaminopropyl)-indol-3-yl)-3-(indol-3-yl)maleimide
- 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, Bisindolylmaleimide I, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione
- 3-[1-[3-(DiMethylaMino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrol-2,5-dione
- BisindolylMaleiMide I (free base) [GF-109203X
- G 6850]
- BIM 1
- CS-1080
- RBT205 INHIBITOR
- InSolution Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem
- Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem
- BISINDOLYLMALEIMIDE I;GO 6850
- GF109203X USP/EP/BP
- Estorra
- GF109203X Go-6850
- 133052-90-1
- C25H24N4O2HCl
- C25H24N4O2
- C27H26N4O2
- Cell Biology
- Biochemicals and Reagents
- BioChemical
- Enzymes, Inhibitors, and Substrates
- Serine/Threonine Kinase Inhibitors
- Protein Kinase Inhibitors and Related Products
- Protein Kinase C and Glycogen Synthase Kinase 3 (PKC & GSK3)
- Protein Kinases and Phosphatases
- Kinase/Phosphatase Biology
- Cell Signaling and Neuroscience
- TGF-beta/Smad
- Inhibitors
- Smad
- TGF-beta
- Protein Kinase
- inhibitor
