Nalmefene
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- CAS-Nr.
- 55096-26-9
- Englisch Name:
- Nalmefene
- Synonyma:
- C08027;NALMEFENE;ORF-11676;nalmetrene;Nalmefene d3;Nalmefene-D7;NalMefene USP;6-Deoxo-6-methylenenaltrexone;6-desoxy-6-methylenenaltrexone;4,5α-Epoxy-6-methylene-17-(cyclopropylmethyl)morphinan-3,14-diol
- CBNumber:
- CB1747788
- Summenformel:
- C21H25NO3
- Molgewicht:
- 339.44
- MOL-Datei:
- 55096-26-9.mol
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Nalmefene Eigenschaften
- Schmelzpunkt:
- 182-185?C
- Siedepunkt:
- 507.9±50.0 °C(Predicted)
- Dichte
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
- Aggregatzustand
- Solid
- pka
- pKa 7.63(H2O) (Uncertain)
- Farbe
- White to Off-White
- CAS Datenbank
- 55096-26-9
- NIST chemische Informationen
- Nalmefene(55096-26-9)
Nalmefene Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Off-White Solid
Verwenden
A structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist.
Biologische Funktion
Nalmefene (Revex) is a long-acting injectable pure opioid
antagonist recently introduced in the United States.
It binds all opioid receptors and reverses the effects of
opioid agonists at those receptors.The onset of action is 2 minutes after IV administration. Hepatic metabolism
is slow and occurs via glucuronide conjugation to inactive
metabolites. Its half-life of 11 hours is about 5 times
that of naloxone. Indications include use in postoperative
settings to reverse respiratory depression and in
opioid overdose. Due to the long duration of action of
nalmefene, however, naloxone may be preferred for
treatment of overdose because it produces a shorter duration
of withdrawal effects.
Allgemeine Beschreibung
Nalmefene (Revex) is a pure opioid antagonist that is the6-methylene analog of naltrexone. It is available as a solutionfor IV, IM, or subcutaneous (SC) administration toreverse the effects of opioids after general anesthesia andin the treatment of overdose. It is longer acting than naloxonebut otherwise has a similar pharmacodynamic andmetabolic (3-glucuronidation) profile. Nalmefene hashigher oral bioavailability (approximately 40%) thannaloxone or naltrexone and is currently being investigatedas an oral treatment for pathological gambling and alcoholabuse.
Nalmefene Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nalmefene Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 64)Lieferanten
55096-26-9()Verwandte Suche:
- [5ALPHA]-17-[CYCLOPROPYLMETHYL]-4,5-EPOXY-6-METHYLENEMORPHINAN-3,14-DIOL
- 17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol
- NALMEFENE
- (5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinon-3,14-diol
- 6-desoxy-6-methylenenaltrexone
- nalmetrene
- (5α)-17-(cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
- 6-Deoxo-6-methylenenaltrexone
- 9a-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylen-3,14-morphinandiol
- 17-(Cyclopropylmethyl)-4,5α-epoxy-6-methylenemorphinan-3,14-diol
- 4,5α-Epoxy-6-methylene-17-(cyclopropylmethyl)morphinan-3,14-diol
- C08027
- (5α)-17-(d3-Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
- Nalmefene d3
- ORF-11676
- NalMefene USP
- Morphinan-3,14-diol,17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5a)-
- (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylene-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
- Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5α)-
- Nalmefene-d3Q: What is
Nalmefene-d3 Q: What is the CAS Number of
Nalmefene-d3
- Nalmefene-D7
- 55096-26-9
- C21H22D3NO3
- Aromatics
- Drug Analogues
- Intermediates & Fine Chemicals
- Isotope Labelled Compounds
- Neurochemicals
- Pharmaceuticals
