LATRUNCULIN A
|
|
|
- CAS-Nr.
- 76343-93-6
- Englisch Name:
- LATRUNCULIN A
- Synonyma:
- LAT-A;NSC 613011;LATRUNCULIN A;Latrunculin A (LAT-A);LATRUNCULIN A, LATRUNCULIA MAGNIFICA;Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem;4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone;(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone;2-Thiazolidinone, 4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-, (4R)-;[1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-HYDROXY-5,12-DIMETHYL-3-OXO-2,16-DIOXABICYCLO[13.3.1]NONADECA-4,8,10-TRIEN-17-YL)-2-THIAZOLIDINONE
- CBNumber:
- CB1679575
- Summenformel:
- C22H31NO5S
- Molgewicht:
- 421.55
- MOL-Datei:
- 76343-93-6.mol
|
LATRUNCULIN A Eigenschaften
- alpha
- D24 +152° (c = 1.2 in chloroform)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble
- Aggregatzustand
- waxy solid
- Farbe
- yellow
- Optische Aktivit?t
- +144.423 （CHCl3）
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
|
| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P233 |
Beh?lter dicht verschlossen halten. |
| P240 |
Beh?lter und zu befüllende Anlage erden. |
| P241 |
Explosionsgeschützte [elektrische/Lüftungs-/ Beleuchtungs-/...] Ger?te verwenden. |
| P242 |
Nur funkenfreies Werkzeug verwenden. |
| P243 |
Ma?nahmen gegen elektrostatische Entladungen treffen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P370+P378 |
Bei Brand: zum L?schen verwenden. |
| P403+P235 |
An einem gut belüfteten Ort aufbewahren. Kühl halten. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
LATRUNCULIN A Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Actin disruption is used to study cell functions
in vitro (
e.g., migration, endocytosis) and
in vivo (
e.g., tumor cell invasion). Latrunculin A is a bioactive 2-
thiazolidinone macrolide derived from sponges that sequesters G-
actin and prevents F-
actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both
in vitro (K
d = 0.2 μM) and in cells (0.5 μM, 30 min).{ Latrunculin A (1-
10 μM) causes depolymerization of tumor cell cytoskeleton within ten minutes. Overnight treatment of cells with latrunculin A (10 μM) strongly suppresses actin synthesis. Prolonged cell treatment blocks dexamethasone-
induced changes in actin cytoskeleton with no effect on cell viability.
Verwenden
Latrunculin A, Latrunculia magnifica is a stabilizer of monomeric G-actin and polymerization inhibitor.
Definition
ChEBI: A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia myc
fijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.
Allgemeine Beschreibung
Latrunculin A, a toxin extracted from the red sea sponge
Latrunculia magnifica. It participates
in vitro in the morphological alteration of the polymerization of pure actin. It forms a complex by binding with the nucleotide cleft of actin for actin filaments elongation.
LATRUNCULIN A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
LATRUNCULIN A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 58)Lieferanten
76343-93-6()Verwandte Suche:
- [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-HYDROXY-5,12-DIMETHYL-3-OXO-2,16-DIOXABICYCLO[13.3.1]NONADECA-4,8,10-TRIEN-17-YL)-2-THIAZOLIDINONE
- LAT-A
- LATRUNCULIN A
- LATRUNCULIN A, LATRUNCULIA MAGNIFICA
- LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
- (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone
- 4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
- NSC 613011
- Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem
- 2-Thiazolidinone, 4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-, (4R)-
- Latrunculin A (LAT-A)
- 76343-93-6
- C22H31NO5S
- Cytoskeleton and Extracellular Matrix
- BioChemical
- Actin Inhibitors and Probes
- Cell Biology
- Cell Signaling and Neuroscience
