Germacrone
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- CAS-Nr.
- 6902-91-6
- Englisch Name:
- Germacrone
- Synonyma:
- Germacron;3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-;3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (3E,7E)-;GERMACRONE;Germacrone-RM;GERMACRONE(RG);GerMacrol (obsol;(E,E)-GerMacrone;GERMACRONE(RG) 1mg;Germacrone, 10 mM in DMSO
- CBNumber:
- CB1497650
- Summenformel:
- C15H22O
- Molgewicht:
- 218.33
- MOL-Datei:
- 6902-91-6.mol
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Germacrone Eigenschaften
- Schmelzpunkt:
- 55-58 °C
- Siedepunkt:
- 153-157 °C(Press: 13 Torr)
- Dichte
- 0.9908 g/cm3
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- maximale Wellenl?nge (λmax)
- 309nm(MeOH)(lit.)
- BRN
- 2047453
- Stabilit?t:
- Light Sensitive
- LogP
- 4.760 (est)
- CAS Datenbank
- 6902-91-6
- NIST chemische Informationen
- 3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (e,e)-(6902-91-6)
Germacrone Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities. It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 μM. Germacrone (50-250 μM) enhances cytotoxicity and apoptosis induced by doxorubicin in doxorubicin-resistant MCF-7/adr cells.
In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity. It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
Verwenden
Germacrone is an antiviral isolate of Geranium macrorrhizum which inhibits and prevents early stage influenza virus infection. It also inhibits the proliferation of glioma cells by promoting apoptosis.
Hazard
A poison by ingestion
Sicherheitsprofil
A poison by ingestion.
When heated to decomposition it emits
acrid smoke and irritating vapors.
Germacrone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Germacrone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 200)Lieferanten
6902-91-6()Verwandte Suche:
Erythrit
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenon
[1aS-(1aα,1bβ,2β,5aβ,6β,6aα)]-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranosid
- (E,E)-Germacra-3,7(11),9-trien-6-one
- (E,E)-3,7-Dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one
- 3,7-Dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one
- Germacra-3,7(11),9-trien-6-one, (E,E)-
- trans,trans-3,7-Dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one
- (3E,7E)-3,7-Dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one
- GERMACRONE(RG)
- GERMACRONE
- (3E,7E)-10-Isopropylidene-3,7-diMethyl-3,7-cyclodecadien-1-one
- (3E,7E)-3,7-DiMethyl-10-(propan-2-ylidene)cyclodeca-3,7-dienone
- GerMacrol (obsol
- (E,E)-GerMacrone
- (3z,7z)-3,7-dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one
- (3E,7E)-3,7-dimethyl-10-propan-2-ylidenecyclodeca-3,7-dien-1-one
- Germacrone, 98%, from Curcuma zedoaria (Christm.) Rosc
- 3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-
- Germacron
- 3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (3E,7E)-
- (3E, 7E) -3,7-dimethyl-10- (propyl-2-ylidene) cyclodecane-3,7-dien-1-one
- GERMACRONE(RG) 1mg
- Germacrone-RM
- Germacrone, 10 mM in DMSO
- 6902-91-6
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Inhibitors
