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Pomalidomide-PEG5-CO2H

Pomalidomide-PEG5-CO2H Struktur
2139348-63-1
CAS-Nr.
2139348-63-1
Englisch Name:
Pomalidomide-PEG5-CO2H
Synonyma:
Pomalidomide-PEG5-COOH;Pomalidomide-PEG5-CO2H;POMALIDOMIDE-PEG 5-CO 2 H;Pomalidomide 4'-PEG5-acid;Thalidomide-NH-PEG5-C2-COOH;Pomalidomide-PEG5-CO2H >=98%;Pomalidomide-PEG5-CO2H ISO 9001：2015 REACH;1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12,15-pentaoxaoctadecan-18-oic Acid;1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid;1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
CBNumber:
CB14846412
Summenformel:
C26H35N3O11
Molgewicht:
565.57
MOL-Datei:
2139348-63-1.mol

Pomalidomide-PEG5-CO2H Eigenschaften

Siedepunkt:
791.0±60.0 °C(Predicted)
Dichte
1.360±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.28±0.10(Predicted)
Aggregatzustand
Solid-Liquid Mixture
Farbe
White to yellow

Sicherheit

Pomalidomide-PEG5-CO2H Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG5-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG5-CO2H Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pomalidomide-PEG5-CO2H Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 34)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22787 58
Henan Alfa Chemical Co., Ltd
China 12341 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Nanjing Bicbiotechnology Co., Ltd 		+86-2552131256 +86-18251840740
 sales@bicbiotech.com China 5994 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068
 1924344760@confluore.cn China 2996 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 18021050169
 market@aladdin-e.com China 25003 65
Mashilabs (Shanghai) Co.,Ltd. 19916721580
 mafarm@126.com China 4294 58
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
  • POMALIDOMIDE-PEG 5-CO 2 H
  • Pomalidomide-PEG5-CO2H
  • Propanoic acid, 3-[[14-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradec-1-yl]oxy]-
  • Pomalidomide-PEG5-CO2H >=98%
  • Pomalidomide-PEG5-COOH
  • Pomalidomide-PEG5-CO2H ISO 9001：2015 REACH
  • Pomalidomide 4'-PEG5-acid
  • 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
  • Thalidomide-NH-PEG5-C2-COOH
  • 1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12,15-pentaoxaoctadecan-18-oic Acid
  • 1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
  • 2139348-63-1
  • peg
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