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HS-10296

HS-10296 Struktur
1899921-05-1
CAS-Nr.
1899921-05-1
Englisch Name:
HS-10296
Synonyma:
HS-10296;Almonertinib;HS 10296;HS10296;2H6]-Almonertinib;Almonertinib (HS-10296);HS-10296;HS 10296;HS10296;1899921-05-1;N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide;N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-;inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC
CBNumber:
CB14808621
Summenformel:
C30H35N7O2
Molgewicht:
525.66
MOL-Datei:
1899921-05-1.mol

HS-10296 Eigenschaften

Dichte
1.24±0.1 g/cm3(Predicted)
L?slichkeit
DMSO:91.67(Max Conc. mg/mL);174.38(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);11.41(Max Conc. mM)
pka
12.68±0.70(Predicted)
Aggregatzustand
Solid
Farbe
Off-white to light yellow

Sicherheit

HS-10296 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

HS-10296 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

HS-10296 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 62)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd 		+8613367258412
 ada@ipurechemical.com China 10319 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Chemtour Biotech Co., Ltd 		+8617327281506
 market@chemtour.com China 1460 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 10986 58
  • HS-10296
  • N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide
  • HS-10296;HS 10296;HS10296;1899921-05-1
  • HS 10296;HS10296
  • Almonertinib (HS-10296)
  • Almonertinib
  • 2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-
  • N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
  • 2H6]-Almonertinib
  • inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC
  • 1899921-05-1
  • C30H35N7O2
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