Ryanodol-3-(1H-pyrrol-2-carboxylat) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R21/22:Gesundheitssch?dlich bei Berührung mit der Haut und beim Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.

S-S?tze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

Beschreibung

Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).

Chemische Eigenschaften

white to off-white solid

Verwenden

Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.

Definition

ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.

Biologische Aktivit?t

Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

Einzelnachweise

Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)

Ryanodol-3-(1H-pyrrol-2-carboxylat) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Ryanodol-3-(1H-pyrrol-2-carboxylat) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32268	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30230	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38660	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39927	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jk.info@jkchemical.com	China	96815	76
	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
Shanghai Macklin Biochemical Co.,Ltd.	15221275939	shenlinxing@macklin.cn	China	15874	55

15662-33-6(Ryanodol-3-(1H-pyrrol-2-carboxylat))Verwandte Suche:

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• Ryanex
• Ryanexcel
• Ryanodine,99%
• 6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate ryania
• Ryanodine from Ryania speciosa
• Ryanodol 3-(1H-pyrrole-2-carboxylate) from Ryania speciosa
• RYANODINE MIXTURE
• RYANADOL
• RYANADOL 3-(1H-PYRROLE-2-CARBOXYLATE)
• Ryania(content>30%)
• Ryanicide
• RYANODINE
• RYANODOL-3-(1H-PYRROLE-2-CARBOXYLATE)
• 1H-PYRROLE-2-CARBOXYLIC ACID, (3S,4R,4AR,6S,7S,8R,8AS,8BR,9S,9AS)-DODECAHYDRO-4,6,7,8A,8B,9A-HEXAHYDROXY-3,6A,9-TRIMETHYL-7-(1-METHYLETHYL)-6,9-METHANOBENZO[1,2]PENTALENO[1,6-BC]FURAN-8-YL ESTER
• 3-(1H-PYR-ROLE-2-CARBOXYLATE)
• bonideryatox
• groundryaniaspecisa(vahl)stemwood(alkoloidryanodine)
• ryanexel
• ryania
• ryaniapowder
• ryaniaspeciosa
• ryanodinealkaloid
• 6-(1alpha,5abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate
• RYANODINE >98% (RYANADOL, 3-(1H-PYRR
• RYANODINE FROM RYANIA SPECIOSA MINIMUM &
• RYANODINE FROM RYANIA SPECIOSA INHIBITS CALCIUM RELEASE FROM THE SARCOPLASMIC RETICULUM
• RYANODINE FROM RYANIA SPECIOSA A MIXTURE OF RYANODINE AND 9,21-DEHYDRORYANODINE (1:1)
• RYANODINE HIGH PURITY
• 1H-Pyrrole-2-carboxylicacid(3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethy]
• 9,21-DEHYDRO(RG)
• Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem
• 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
• Ryanodine, Ca2+ release modulator
• 15662-33-6
• C25H35NO9
• Signalling
• Alkaloids
• InsP3/Ryanodine receptor