Fmoc-Tyr(Me)-OH
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- CAS-Nr.
- 77128-72-4
- Englisch Name:
- Fmoc-Tyr(Me)-OH
- Synonyma:
- Fmoc;FMOC-L-TYR(ME);FMOC-TYR(ME)-OH;FMOC-TYR(AL)-OH;FMOC-L-TYR(ME)-OH;Fmoc-4-Methoxy-Phe;FMOC-PHE(4-OME)-OH;FMOC-L-4-METHOXYPHE;Fmoc-L-4-MeO-Phe-OH;Methoxy phenylalanine
- CBNumber:
- CB1468274
- Summenformel:
- C25H23NO5
- Molgewicht:
- 417.45
- MOL-Datei:
- 77128-72-4.mol
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Fmoc-Tyr(Me)-OH Eigenschaften
- Schmelzpunkt:
- 161 °C
- Siedepunkt:
- 647.8±55.0 °C(Predicted)
- Dichte
- 1.274±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- Aggregatzustand
- powder to crystal
- pka
- 2.97±0.10(Predicted)
- Farbe
- White to Almost white
- InChIKey
- JYQODLWFOPCSCS-QHCPKHFHSA-N
- SMILES
- C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- CAS Datenbank
- 77128-72-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 2 water endangering |
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| HazardClass |
IRRITANT |
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| HS Code |
29242990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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Fmoc-Tyr(Me)-OH Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.
Chemische Eigenschaften
White to off-white powder
Synthese
Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.
Fmoc-Tyr(Me)-OH Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fmoc-Tyr(Me)-OH Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 195)Lieferanten
77128-72-4()Verwandte Suche:
- Fmoc-4-Methoxy-L-Phe-OH
- Methoxy phenylalanine
- N-FMoc-4-Methoxy-L-phenylalanine, 95%
- FMoc-Tyr(Me)-OH FMoc-O-Methyl-L-tyrosine
- FMOC-(S)-b-(p-Methoxyphenyl)alanine
- (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-Methoxyphenyl)propanoic acid
- N-Fmoc-O-methyl-L-tyrosine, >=99%
- Fmoc-4-Methoxy-Phe
- N-ALPHA-FMOC-O-METHYL-L-TYROSINE
- N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-METHYL-L-TYROSINE
- N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHYL-L-TYROSINE
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine
- Fmoc-O-methyl-L-tyrosine≥ 99% (HPLC)
- Fmoc-Tyr(Me)-OH Novabiochem
- N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHY-L-TYROSINE
- N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-METHOXY-L-PHENYLALANINE
- (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-(4-METHOXY-PHENYL)-PROPIONIC ACID
- FMOC-4-METHOXY-PHE-OH
- FMOC-4-METHOXY-L-PHENYLALANINE
- FMOC-4-METHOXYPHENYLALANINE
- FMOC-L-4-METHOXYPHE
- FMOC-TYR(ME)-OH
- FMOC-L-TYR(ME)
- FMOC-L-TYR(ME)-OH
- FMOC-L-TYROSINE(METHYL ETHER)
- FMOC-P-METHOXY-PHE-OH
- FMOC-PHE(4-OME)-OH
- FMOC-O-METHYL-L-TYROSINE
- FMOC-4-METHOXYPHENYLALANINE MIN 99%
- Fmoc-L-4-MeO-Phe-OH
- FMOC-TYR(AL)-OH
- (9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(Me)-OH
- (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxyphenyl)propanoic acid
- Fmoc-Tyr(Me)-OH(Fmoc-4-Methoxy-Phe)
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine>
- Fmoc-Tyr(Me)-OH (N-Fmoc-O-methyl-L-tyrosine)
- L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-
- N-Fmoc-4-methoxy-L-phenylalanine,95%
- N-Fmoc-O-methyl-L-tyrosine
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxy-L-phenylalanine
- FMOC-TYR(ME)-OH USP/EP/BP
- Fmoc
- 77128-72-4
- Phenylalanine [Phe, F]
- Unusual Amino Acids
- Amino Acids
- Fmoc-Amino acid series
