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Anti-WRN antibody, Mouse monoclonal

Anti-WRN antibody, Mouse monoclonal Struktur
CAS-Nr.
Englisch Name:
Anti-WRN antibody, Mouse monoclonal
Synonyma:
MONOCLONAL ANTI-WRN;Anti-WRN antibody, Mouse monoclonal
CBNumber:
CB14669815
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Anti-WRN antibody, Mouse monoclonal Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous solution
Biologische Quelle
mouse

Sicherheit

Anti-WRN antibody, Mouse monoclonal Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-WRN antibody has been used in
  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunoprecipitation
  • immunohistochemistry
  • western blotting

Allgemeine Beschreibung

Anti-WRN antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the hybridoma 195C produced by the fusion of mouse myeloma cells (p3-NS1/Ag4-1) and splenocytes from BALB/c mice immunized with a recombinant fusion protein fragment of human WRN. Werner syndrome ATP-dependent helicase (WRN) is located on chromosome 8 and is 167 kDa. The WRN protein belongs to the RecQ helicase family of DNA helicases.

Biochem/physiol Actions

Werner syndrome ATP-dependent helicase (WRN) protein has been demonstrated to possess three known catalytic activities: 3′-5′ helicase, exonuclease and ATPase activities. The C-terminal region of the protein contains a nuclear localization signal (NLS), thus targeting WRN protein to the nucleus, nucleolus and nucleoplasmic foci. The involvement of WRN in multiple DNA metabolic process suggests its function as a tumor suppressor. Mutations in the WRN protein results in Werner syndrome (WS). The epigenetic inactivation of WRN leads to loss of WRN-exonuclease activity, resulting in increased chromosomal instability and hypersensitivity to chemotherapeutic drugs.

Anti-WRN antibody, Mouse monoclonal Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Anti-WRN antibody, Mouse monoclonal Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Merck KGaA (+86) 21 2033 8288
sigmaname@qq.com CHINA 292394 58

  • MONOCLONAL ANTI-WRN
  • Anti-WRN antibody, Mouse monoclonal
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