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Tenofovir alafenamide hemifumarate

Tenofovir alafenamide hemifumarate Struktur
1392275-56-7
CAS-Nr.
1392275-56-7
Englisch Name:
Tenofovir alafenamide hemifumarate
Synonyma:
Tenofovir Alafenamide fumarate;GS7340(Tenofovir Alafenamide Fumarate);N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1);L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1);Anti-HIV;API-Anti-HBV;Tenofovir Alafenamid;GS-7340 (hemifumarate);Alafenamide hemifumarate;Tenofovir levamide amine fumarate
CBNumber:
CB13038481
Summenformel:
C25H33N6O9P
Molgewicht:
592.55
MOL-Datei:
1392275-56-7.mol

Tenofovir alafenamide hemifumarate Eigenschaften

storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
L?slichkeit
DMSO:75.0(Max Conc. mg/mL);70.16(Max Conc. mM)
Aggregatzustand
Solid
Farbe
White to off-white
CAS Datenbank
1392275-56-7
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Tenofovir alafenamide hemifumarate Chemische Eigenschaften,Einsatz,Produktion Methoden

Definition

ChEBI: Tenofovir alafenamide fumarate is a fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection. It has a role as an antiviral drug, a HIV-1 reverse transcriptase inhibitor and a prodrug. It contains a tenofovir alafenamide(1+).

Arzneimittelwechselwirkung

Some products that may interact with this drug are: adefovir, orlistat, other drugs that may harm the kidneys (including aminoglycosides such as amikacin/gentamicin).

Advantages

One major advantage of the hemifumarate form of tenofovir alafenamide over the monofumarate form is its exceptional capability to purge GS-7339 (i.e., 9-[(R)-2-[[(R)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine, which is the major diastereomeric impurity in the active pharmaceutical ingredient. Thus, the hemifumarate form of tenofovir alafenamide can be more readily and easily separated from impurities than the monofumarate form. Other major advantages of tenofovir alafenamide hemifumarate over the monofumarate form include improved thermodynamic and chemical stability (including long-term storage stability), superior process reproducibility, superior drug product content uniformity, and a higher melting point.

Tenofovir alafenamide hemifumarate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tenofovir alafenamide hemifumarate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 326)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zison Pharmaceutical (Shandong) Co., Ltd.
+86-0086-531-88259693 +86-18660188356
tracy.li@zisonpharm.com China 78 58
ENBRIDGE PHARMTECH CO., LTD.
+8613812269233
tinayang@enbridgepharm.com China 322 58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.
+8615065888978
admin@hsnordpharma.com China 92 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 474 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60

  • GS-7340 (hemifumarate)
  • Anti-HIV
  • API-Anti-HBV
  • (S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1)
  • (R)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate
  • N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
  • Tenofovir alafenamide hemifumarate
  • TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
  • Tenofovir levamide amine fumarate
  • (Tenofovir alafenamide : fumarate = 2:1)
  • (S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate hemifumarate
  • Tenofovir Alafenamide fumarate [USAN]
  • Alafenamide hemifumarate
  • Tenofovir Alafenamide Hemifumarate(2:1)
  • Tenofovir Alafenamide Fumarate USP/EP/BP
  • Tenofovir Alafenamid
  • Tenofovir Alafenamide Hemifumarate salt[USAN
  • Tenofovir alafenamide hemifumarate (GS-7340)
  • Tenofovir Alafenamide Hemifumarate salt
  • Tenofovir Alafenamide fumarateQ: What is Tenofovir Alafenamide fumarate Q: What is the CAS Number of Tenofovir Alafenamide fumarate
  • L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)
  • N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1)
  • GS7340(Tenofovir Alafenamide Fumarate)
  • 3H-1,2,4-Triazole-3-thione,4-amino-2,4-dihydro-5-(10-methoxyphenyl)-
  • Tenofovir Alafenamide fumarate
  • Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate hemifumarate
  • Tenofovir dipivoxil phenol amine fumarate
  • 2-fluoro-5-[(4' -0x0-3'H-phthalazin-1'-yl)methyllbenzoic acide'
  • Tenofovir Alafenamide Hemifumarate(2:1) CRS
  • Tenofovir Alafenamide Fumarate API
  • GS-7340 (hemifumarate)|||Tenofovir alafenamide fumarate
  • Celiprolol Impurity 8(Celiprolol EP Impurity H)
  • TAF(Tenofovir Alafenamide Hemifumarate)
  • 1392275-56-7
  • C46H62N12O14P2
  • 2C21H29N6O5PC4H4O4
  • API
  • 1392275-56-7
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