affinity isolated antibody Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-Epsin1 (internal) antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
Allgemeine Beschreibung
Epsin1 is an endocytic adaptor protein. It contains an epsin N-terminal homology (ENTH) region, a single clathrin-binding LVDLD motif and two or three tandem ubiquitin-interacting motifs (UIMs). It is localized on the human chromosome at 19q13.42.
Biochem/physiol Actions
Epsin1 plays a central role in the clathrin-mediated internalization and degradation of ubiquitinated proteins. It interacts with Eps15 subunit of the clathrin adaptor AP2, clathrin and other accessory proteins. Epsin1 plays a role in the recruitment of ubiquitinated epidermal growth factor receptor (EGFR) into clathrin-coated pits. Epsin1 is required in the mitotic membrane and spindle organization. Overexpression of epsin1 is associated with fibrosarcoma cell invasion.
affinity isolated antibody Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
