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Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Struktur
922507-80-0
CAS-Nr.
922507-80-0
Englisch Name:
Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
Synonyma:
16F16,16F-16;PDI inhibitor 16F16;PDI inhibitor 16F16 >=98% (HPLC);Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate;2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester;1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-, methyl ester
CBNumber:
CB12751042
Summenformel:
C16H17ClN2O3
Molgewicht:
320.77
MOL-Datei:
922507-80-0.mol

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Eigenschaften

storage temp. 
2-8°C
L?slichkeit
DMSO: soluble12mg/mL, clear
Aggregatzustand
powder
Farbe
white to tan

Sicherheit

WGK Germany  3

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.

Biochem/physiol Actions

16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 12)Lieferanten
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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Sigma-Aldrich 021-61415566 800-8193336
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
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Energy Chemical 021-58432009 400-005-6266
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JiangSu Star Science Co.,Ltd 400-400-605-7200-7200 17312445705
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TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24647 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939
 shenlinxing@macklin.cn China 29794 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337
 3427709316@qq.com China 7979 58
  • Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
  • PDI inhibitor 16F16
  • 2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester
  • 1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-, methyl ester
  • PDI inhibitor 16F16 >=98% (HPLC)
  • 16F16,16F-16
  • 922507-80-0
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