SID 24769845
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- CAS-Nr.
- 949898-66-2
- Englisch Name:
- SID 24769845
- Synonyma:
- AS-136A;SID 24769845;CID 16122506;2-methyl-N-(4-piperidin-1-ylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3-carboxamide;1-Methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide;1H-Pyrazole-5-carboxamide, 1-methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-
- CBNumber:
- CB12750959
- Summenformel:
- C17H19F3N4O3S
- Molgewicht:
- 416.42
- MOL-Datei:
- 949898-66-2.mol
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SID 24769845 Eigenschaften
- Dichte
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- powder
- pka
- 12.28±0.70(Predicted)
- Farbe
- white to off-white
SID 24769845 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
AS-136A is a small molecule developed as part of the NIH Probes effort. AS-136A is a potent measles virus (MeV) RNA-dependent RNA polymerase (RdRp) inhibitor. AS-136A is very stable, decreases virus titer after 24 hours in physiological conditions, and serves as a positive control in MeV inhibitory assays.
Biochem/physiol Actions
AS-136A is a potent measles virus RdRp inhibitor. Measles virus (MV) is a member of the paramyxovirus family. Ribavirin (R9644) is the only drug available for treatment of paramyxoviruses, and it has limited efficacy against MV. A series of small molecules has been developed to inhibit viral RNA-dependent RNA polymerase (RdRp), a protein vital to infection leading to the development of AS-136A, a very potent RdRp inhibitor. AS-136A has high stability and continues to decrease virus titer after 24 hours in physiologic conditions. AS-136A is now used as a positive control in experiments assaying MV inhibition. This compound is a product of the NIH Probes effort, also known as SID 24769845.
SID 24769845 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SID 24769845 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 4)Lieferanten
- 1-Methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
- AS-136A
- CID 16122506
- SID 24769845
- 2-methyl-N-(4-piperidin-1-ylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3-carboxamide
- 1H-Pyrazole-5-carboxamide, 1-methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-
- 949898-66-2
- C17H19F3N4O3S
