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[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Struktur
1360705-96-9
CAS-Nr.
1360705-96-9
Englisch Name:
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
Synonyma:
ML 210;CID 49766530;ML 210 >=98% (HPLC);ML 210 - CID 49766530;[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone;(4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone;Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-;[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone;residue,Ferroptosis,inhibit,peroxidase,ML-210,Covalent,selenocysteine,Glutathione Peroxidase,ML 210,ML210,glutathione,Inhibitor,GPX4,anti-cancer
CBNumber:
CB12750494
Summenformel:
C22H20Cl2N4O4
Molgewicht:
475.32
MOL-Datei:
1360705-96-9.mol

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Eigenschaften

Siedepunkt:
644.7±55.0 °C(Predicted)
Dichte
1.415±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
Soluble in DMSO (up to 30 mg/ml)
pka
4.69±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

ML 210 has been used as a glutathione peroxidase 4 (GPX4) inhibitor to induce ferroptosis in cancer cells. It has also been used as a GPX4 inhibitor to examine whether pharmacological inhibition of GPX4 altered prominin2 expression and impacted ferroptosis in adherent MCF10A and Hs578t cells.

Biochem/physiol Actions

ML 210 induces non-apoptotic cell death in tumor cells expressing the RAS oncogene.

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

5-METHYL-4-NITRO-3-ISOXAZOLECARBOXYLIC ACID

Downstream Produkte

[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 55)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
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InvivoChem 		+1-708-310-1919 +1-13798911105
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TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33338 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580
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1360705-96-9()Verwandte Suche:

  • [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
  • CID 49766530
  • ML 210
  • [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone
  • ML 210 - CID 49766530
  • Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-
  • ML 210 >=98% (HPLC)
  • (4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
  • residue,Ferroptosis,inhibit,peroxidase,ML-210,Covalent,selenocysteine,Glutathione Peroxidase,ML 210,ML210,glutathione,Inhibitor,GPX4,anti-cancer
  • 1360705-96-9
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