(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
|
|
|
- CAS-Nr.
- 608141-43-1
- Englisch Name:
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
- Synonyma:
- Apremilast Impurity 62;RSSYY(Lurasidone Hydrochloride)-15;(2S)-2-acetamido-4-methylpentanoate;Apremilast Impurity 2 N-Acetyl-L-Leucine Salt;Apremilast Impurity 4 N-Acetyl-L-Leucine Salt;Apremilast Impurity 35 N-acetyl-L-leucine Salt;Apremilast Impurity 21 N-Acetyl-L-Leucine Salt;Apremilast Impurity 55(N-Acetyl-L-leucine Salt);(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin...;[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]azanium
- CBNumber:
- CB12707852
- Summenformel:
- C20H34N2O7S
- Molgewicht:
- 446.56
- MOL-Datei:
- 608141-43-1.mol
|
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Eigenschaften
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- CAS Datenbank
- 608141-43-1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt is prepared by the reaction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine and N-Acetyl-L-leucine. The specific synthesis steps are as follows:
A 3 L 3-necked round bottom flask was equipped with a mechanical stirrer, thermometer, and condenser and charged with 2-(3 -ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine (137.0 g, 500 mmol), N-acetyl-L-leucine (52 g, 300 mmol), and methanol (1.0 L). The stirred slurry was heated to reflux for 1 hour. The stirred mixture was allowed to cool to ambient temperature and stirring was continued for another 3 hours at ambient temperature. The slurry was filtered andwashed with methanol (250 mL). The solid was air-dried and then dried in vacuo at ambient temperature to a constant weight, giving 109.5 g (98percent yield) of the crude product (85.8percent ee). The crude solid (55.0 g) and methanol (440 mL) were brought to reflux for 1 hour, cooled to room temperature and stirred for an additional 3 hours at ambient temperature. The slurry was filtered and the filter cake was washed with methanol (200 mL). The solid was air-dried and then dried invacuo at 30°C. to a constant weight, yielding 49.6 g (90percent recovery) of(S)-2-(3-ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine-N-acety l-L-leucine salt (98.4percent ee). ChiralHPLC (1/99 EtOH/20 mM KH2PO4 pH 7.0, Ultron Chiral ES-OVS from Agilent Technologies,150 mm4.6 mm, 0.5 mL/min., 240 nm): 18.4 mm (S-isomer, 99.2percent), 25.5 mm (R-isomer,0.8percent).
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 185)Lieferanten
608141-43-1()Verwandte Suche:
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
- N-Acetyl-L-leucine compound with (alphaS)-3-ethoxy-4-methoxy-alpha-[(methylsulfonyl)methyl]benzenemethanamine
- (2S)-2-acetamido-4-methylpentanoate
- [(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]azanium
- (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine acetyl-L-leucinate
- (1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethylamine N-acetyl L-leucine salt
- (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (S)-2-acetamido-4-methylpentanoate
- (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-Acetyl-L-leucine Salt
- L-Leucine, N-acetyl-, compd. with(aS)-3-ethoxy-4-methoxy-a-[(methylsulfonyl)methyl]benzenemethanamine (1:1)
- Apremilast Impurity 62
- Apremilast Impurity 55(N-Acetyl-L-leucine Salt)
- (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin...
- RSSYY(Lurasidone Hydrochloride)-15
- Apremilast Impurity 35 N-acetyl-L-leucine Salt
- (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methyl
sulfonyl)ethanamine 2-(acetamide methyl)-3- methylbutanoate
- Apremilast Impurity 21 N-Acetyl-L-Leucine Salt
- Apremilast Impurity 2 N-Acetyl-L-Leucine Salt
- (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-acetyl-L-leucinate
- Apremilast Impurity 4 N-Acetyl-L-Leucine Salt
- 608141-43-1
- 608141-43-2
- C12H19NO4SC8H15NO3
- C20H34N2O7S
