(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
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- CAS-Nr.
- 915095-86-2
- Englisch Name:
- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
- Synonyma:
- Englenet Impurity 16;Empagliflozin Impurity 48;2-chloro-4-fluoro-5-Iodobenzophenon;2-Chloro-4'-fluoro-5-iodobenzophenone;2-Chloro-4'-fluoro-5-iodobenzophenone;Empagliflozin Impurity 48 /Englenet Impurity 16;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
- CBNumber:
- CB12651407
- Summenformel:
- C13H7ClFIO
- Molgewicht:
- 360.55
- MOL-Datei:
- 915095-86-2.mol
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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Eigenschaften
- Schmelzpunkt:
- 64-70oC
- Siedepunkt:
- 415℃
- Dichte
- 1.752
- Flammpunkt:
- 205℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- L?slichkeit
- Chloroform (Slightly), Ethyl Acetate
- Aggregatzustand
- Solid
- Farbe
- Off-White
- InChI
- InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H
- InChIKey
- KNYGUQLVFSPVRI-UHFFFAOYSA-N
- SMILES
- C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
24/25 |
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| HS Code |
29142990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.
Synthese
5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained.
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 221)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
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Chongqing Ensky Pharmaceutical Co.,Ltd.
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+86-23-86815286 +86-13983794297
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sales@ensky-chemical.com |
China |
91 |
58 |
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Suzhou Nordica Biopharma CO.,LTD
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+8618136148818
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anna.ran@nordicabio.com |
China |
299 |
58 |
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Cangzhou Kangrui Pharma Tech Co. Ltd.,
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+86-18632776803 +86-13833998158
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cangzhoukangrui@126.com |
China |
733 |
58 |
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Hebei Yanxi Chemical Co., Ltd.
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+8617531190177
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peter@yan-xi.com |
China |
5858 |
58 |
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Shanghai Joiny Pharmaceutical Co.,LTD
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+8613681955282
|
gyd@joiny-pharma.com |
China |
254 |
58 |
|
Capot Chemical Co.,Ltd.
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+86-（0）57185586718 +86-13336195806
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sales@capot.com |
China |
29791 |
60 |
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Shanghai Daken Advanced Materials Co.,Ltd
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+86-371-66670886
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info@dakenam.com |
China |
18648 |
58 |
|
Beijing Cooperate Pharmaceutical Co.,Ltd
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010-60279497
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sales01@cooperate-pharm.com |
CHINA |
1803 |
55 |
|
Henan Tianfu Chemical Co.,Ltd.
|
+86-0371-55170693 +86-19937530512
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info@tianfuchem.com |
China |
21639 |
55 |
|
Shandonghaohong biotechnology Co.,ltd.
|
0635-6175299 13961496334
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sale@inyelchem.com |
CHINA |
44 |
55 |
915095-86-2()Verwandte Suche:
- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
- Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
- (2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone
- Empagliflozin Impurity 48
- Englenet Impurity 16
- 2-chloro-4-fluoro-5-Iodobenzophenon
- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon
- 2-Chloro-4'-fluoro-5-iodobenzophenone
- (2-Chloro-5-iodine phenyl) 4-fluorophenyl) methylone
- Empagliflozin Impurity 48 /Englenet Impurity 16
- 2-Chloro-4'-fluoro-5-iodobenzophenone
- 915095-86-2
- 945065-86-2
- C13H7ClFIO
