3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
|
|
- CAS-Nr.
- 120964-45-6
- Englisch Name:
- 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
- Synonyma:
- DZNepHCl;NSC 617989 HCl;DZNEP; NSC 617989;DZNep hydrochloride;3-deazaneplanocin A HCl;NSC 617989 hydrochloride;3-deazaneplanocin A (DZNeP) HCl;3-Deazaneplanocin hydrochloride;DZNeP (3-deazaneplanocin A) HCl;3-Deazaneplanocin A (hydrochloride)
- CBNumber:
- CB12623932
- Summenformel:
- C12H15ClN4O3
- Molgewicht:
- 298.7255
- MOL-Datei:
- 120964-45-6.mol
|
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Eigenschaften
- Schmelzpunkt:
- 168-169℃
- storage temp.
- -20°C
- L?slichkeit
- H2O: ≥5mg/mL
- Aggregatzustand
- Tan solid
- Farbe
- white to beige
- Wasserl?slichkeit
- Soluble in water (10mM)
- InChIKey
- UNSKMHKAFPRFTI-FDKLLANESA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher |
Xn |
|
|
R-S?tze: |
22 |
|
|
WGK Germany |
3 |
|
|
Bildanzeige (GHS) |
|
Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
Sicherheit |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
3-Deazaneplanocin A is a a powerful inhibitor of S-adenosylhomocysteine hydrolase that has shown potent and selective in vitro and in vivo antiviral activities.
Allgemeine Beschreibung
3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic?property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.
Biochem/physiol Actions
3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 94)Lieferanten
- 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
- 3-Deazaneplanocin A (hydrochloride)
- 3-Deazaneplanocin hydrochloride
- DZNep hydrochloride
- NSC 617989 hydrochloride
- (-)-1-[(1R,4R,5S)-3-(HydroxyMethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aMinoiMidazo[4,5-c]pyridine hydrochloride DZNep hydrochloride
- (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride (1:1)
- 1H-Imidazo[4,5-c]pyridine, 3-cyclopentene-1,2-diol deriv.
- 3-deazaneplanocin A HCl
- 3-deazaneplanocin A (DZNeP) HCl
- NSC 617989 HCl
- (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride
- Histone Methyltransferase EZH2 Inhibitor, DZNep
- Histone Methyltransferase EZH2 Inhibitor, DZNep - CAS 120964-45-6 - Calbiochem
- DZNEP; NSC 617989
- (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride
- 3-Deazaneplanocin A (DZNep) hydrochloride
- DZNEP HYDROCHLORIDE;NSC 617989 HYDROCHLORIDE;3-DEAZANEPLANOCIN HYDROCHLORIDE
- 3-deazaneplanocin A HCl (DZNep HCl)
- DZNepHCl
- 3-Deazaneplanocin A hydrochloride
(DZNep hydrochloride
- 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- USP/EP/BP
- (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
- DZNeP (3-deazaneplanocin A) HCl
- 120964-45-6
- C12H14N4O3HCl
- C12H14N4O3ClH
- Inhibitors
- 1