ISX 9
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- CAS-Nr.
- 832115-62-5
- Englisch Name:
- ISX 9
- Synonyma:
- ISX 9;CS-1582;Isoxazole 9;Isoxazole
(ISX-9);ISX 9(Isoxazole 9);Isoxazole 9 (ISX-9) ;ISX 9, neurogenic agent;Neuronal Differentiation Inducer III;ISX-9;ISX 9;NEURONAL DIFFERENTIATION INDUCER III;N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
- CBNumber:
- CB12574687
- Summenformel:
- C11H10N2O2S
- Molgewicht:
- 234.27
- MOL-Datei:
- 832115-62-5.mol
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ISX 9 Eigenschaften
- Siedepunkt:
- 468.1±35.0 °C(Predicted)
- Dichte
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- -20°
- L?slichkeit
- Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 16 mg/ml).
- pka
- 13.60±0.20(Predicted)
- Aggregatzustand
- solid
- Farbe
- Tan
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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ISX 9 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide was shown to exhibit regulatory effects towards the expression of pH sensing G protein-coupled receptor-68 and is now a new drug target for ischemic heart disease.
Allgemeine Beschreibung
A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 μM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca
2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
ISX 9 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ISX 9 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 128)Lieferanten
- ISX 9
- 3-IsoxazolecarboxaMide, N-cyclopropyl-5-(2-thienyl)-
- N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxaMide
- Neuronal Differentiation Inducer III
- Isoxazole
(ISX-9)
- Isoxazole 9
- Isoxazole 9 (ISX-9)
- ISX 9(Isoxazole 9)
- N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide
- CS-1582
- N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
- ISX-9;ISX 9;NEURONAL DIFFERENTIATION INDUCER III
- ISX 9, neurogenic agent
- 832115-62-5
- Inhibitors
- Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
- API
