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A 419259 trihydrochloride

A 419259 trihydrochloride Struktur
364042-47-7
CAS-Nr.
364042-47-7
Englisch Name:
A 419259 trihydrochloride
Synonyma:
A419259;RK20449;RK-20449;RK 20449;A-419259;A 419259;A-419259 HCl;A 419259 trihydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-;7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CBNumber:
CB12535657
Summenformel:
C29H34N6O
Molgewicht:
482.62
MOL-Datei:
364042-47-7.mol

A 419259 trihydrochloride Eigenschaften

Siedepunkt:
686.4±55.0 °C(Predicted)
Dichte
1.29±0.1 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
H2O: soluble10mg/mL (clear solution)
pka
8.20±0.42(Predicted)
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

WGK Germany  3

A 419259 trihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, <3, <3, and 11.26 nM, respectively)., It is selective for these kinases over c-Abl (IC50 = 3,000 nM) and PKC (IC50 = >33 μM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 μM, respectively), but not Ph- TF-1 and HEL cells. It induces apoptosis in K-562 cells in a concentration-dependent manner. A-419259 (300 nM) inhibits differentiation of murine embryonic stem cells while maintaining pluripotency. It reduces the total number of acute myeloid leukemia (AML) cells, as well as AML stem cells, in the bone marrow and spleen in mouse patient-derived xenograft (PDX) models of AML when administered at a dose of 30 mg/kg twice daily.

A 419259 trihydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

A 419259 trihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 35)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32080 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30241 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38470 58
TargetMol Chemicals Inc. 		+8613564774135
 zijue.cai@tsbiochem.com United States 19863 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4861 58
AdooQ BioScience, LLC +1 (866) 930-6790
info@adooq.com United States 2782 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185
 sales-cpd@caerulumpharma.com China 3466 58
LETOPHARM LIMITED +86-21-5821 5861
sales@letopharm.com China 2384 58
SPIRO PHARMA
eric_feng1954@126.com China 9248 55
  • A 419259
  • A419259
  • A-419259
  • RK 20449
  • RK20449
  • RK-20449
  • 7-[Trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
  • A 419259 trihydrochloride
  • 7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-
  • A-419259 HCl
  • 364042-47-7
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