Omarigliptin (MK-3102)
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- CAS-Nr.
- 1226781-44-7
- Englisch Name:
- Omarigliptin (MK-3102)
- Synonyma:
- OMarigliptin;MK-3102;MK-3102(OMARIGLIPTIN);MK-3012;CS-1519;Ogliptin.;Oralliptin;MK-3102, >=98%;MK 3102:MK-3102;MK-3102 - M10588
- CBNumber:
- CB12516047
- Summenformel:
- C17H20F2N4O3S
- Molgewicht:
- 398.43
- MOL-Datei:
- 1226781-44-7.mol
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Omarigliptin (MK-3102) Eigenschaften
- Siedepunkt:
- 529.4±60.0 °C(Predicted)
- Dichte
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- L?slichkeit
- insoluble in EtOH; insoluble in H2O; ≥17.15 mg/mL in DMSO
- Aggregatzustand
- solid
- pka
- 9.11±0.60(Predicted)
- Farbe
- White to off-white
- InChI
- InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
- InChIKey
- MKMPWKUAHLTIBJ-ISTRZQFTSA-N
- SMILES
- [C@H]1(C2=CC(F)=CC=C2F)OC[C@H](N2CC3=CN(S(C)(=O)=O)N=C3C2)C[C@@H]1N
- CAS Datenbank
- 1226781-44-7
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Omarigliptin (MK-3102) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Merck earned its first global
approval for omarigliptin in Japan in 2015, and phase III
development is ongoing in other countries around the globe for
this interesting small molecule DPP-4 inhibitor. Interestingly,
while most DPP-4 inhibitors used to treat type 2 DM require
daily administration, omarigliptin is a weekly treatment. The
process-scale synthesis of omarigliptin has been nicely
described in an October 2015 paper from the Merck process
group.
Verwenden
Omarigliptin is a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor to be used as treatment for type 2 diabetes.
Omarigliptin (MK-3102) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Omarigliptin (MK-3102) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 250)Lieferanten
- (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-aMine
- MK-3012
- (2S,3R,5S)-2-(2,5-Difluorophenyl)-5-[2-(Methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-aMine (MK-3102 enantioMer)
- (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine
- OMarigliptin (MK-3102)
- 2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine MK3102
- MK-3102 - M10588
- MK-3102, >=98%
- MK-3102
(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-aMine
- (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)te
- Omarigliptin, 98%, a potent, selective and long-acting DPP-4 inhibitor
- Oralliptin
- MK-3102;MK3102;MK 3102
- CS-1519
- MK-3102, Omarigliptin [USAN], Omarigliptin (USAN/INN), SureCN827590, UNII-CVP59Q4JE1, CHEMBL2105762, MK-3102, PB39113
- (2R,3S,5R)-2-(2,5-DIFLUOROPHENYL)- 5-[2-(METHYLSULFONYL)-2,6- DIHYDROPYRROLO[3,4-C]PYRAZOL-5(4H)- YL
- (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
- 2H-Pyran-3-amine, 2-(2,5-difluorophenyl)-5-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-, (2R,3S,5R)-
- Omarigliptin (MK-3102)Q: What is
Omarigliptin (MK-3102) Q: What is the CAS Number of
Omarigliptin (MK-3102) Q: What is the storage condition of
Omarigliptin (MK-3102)
- MK-3102
- OMarigliptin
- MK-3102(OMARIGLIPTIN)
- MK 3102:MK-3102
- Ogliptin.
- Omarigliptin, 10 mM in DMSO
- 1226781-44-7
- C17H20F2N4O3S
- Inhibitors
- API
