ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE
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- CAS-Nr.
- 124755-24-4
- Englisch Name:
- ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE
- Synonyma:
- ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE;Ethyl 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]acetate;Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate;Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate 97%;Di(3,3,3-trifluoroethyl)(ethoxycarbonylmethyl)phosphonate;[Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid ethyl ester;[BIS-(2,2,2-TRIFLUORO-ETHOXY)-PHOSPHORYL]-ACETIC ACID METHYL ESTER;Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, ethyl ester
- CBNumber:
- CB1206274
- Summenformel:
- C8H11F6O5P
- Molgewicht:
- 332.13
- MOL-Datei:
- 124755-24-4.mol
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ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Eigenschaften
- Siedepunkt:
- 249-250 °C(lit.)
- Dichte
- 1.403 g/mL at 25 °C(lit.)
- Brechungsindex
- n20/D 1.3730(lit.)
- Flammpunkt:
- >230 °F
- InChIKey
- HBYHPBCAZBLFTD-UHFFFAOYSA-N
ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Ethyl [Bis(2,2,2-trifluoroethoxy)phosphinyl]acetate is a reagent used in the preparation of spiroketal EBC-23; an anticancer agent, scytonemin A; a novel calcium antagonist and other useful organic compounds.
Synthese
To stirred solution of 18-crown-6 (4.40 g, 16.65 mmol), THF (20 mL), and bis
(2,2,2-trifluoroethyl) phosphite (1) (0.55 mL, 3.75 mmol), KHMDS (8.0 mL, 4.00 mmol,
0.5 M in toluene) was added via syringe in a dropwise manner at -78 oC. Ethyl
chloroacetate (0.35 mL, 3.30 mmol) was added to the flask after 15 min. The reaction
flask was allowed to warm to room temperature and stir for 4 hr. After standard workup
procedure, the crude product was then purified by flash column chromatography (2:1-1:1
hexanes:EtOAc, Rf
= 0.25 in 2:1 hexanes:EtOAc) yielding Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate (808 mg,
2.43 mmol, 73.4%) as a yellow syrup.
ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 66)Lieferanten
124755-24-4()Verwandte Suche:
- Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate
- [BIS-(2,2,2-TRIFLUORO-ETHOXY)-PHOSPHORYL]-ACETIC ACID METHYL ESTER
- ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE
- Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate 97%
- Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, ethyl ester
- [Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid ethyl ester
- Di(3,3,3-trifluoroethyl)(ethoxycarbonylmethyl)phosphonate
- Ethyl 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]acetate
- 124755-24-4
- C8H11F6O5P
- Organic Building Blocks
- Building Blocks
- Phosphonates/Phosphinates
- Phosphorus Compounds
- Organic Building Blocks
- Phosphonates/Phosphinates
- Phosphorus Compounds
